Definition of domains based on a sequence alignment of bacterial intron encoded ORFs

PDF version of alignment
Also see Mitochondrial, chloroplast and bacterial ORFs

N.a.I2 .......... .......... .......... .......... .......... N.a.I1 .......... .......... .......... .......... .......... L.l.I1 .......... .......... .......... .......... .......... B.t.I2 .......... .......... .......... .......... .......... OYPI1 .......... .......... .......... .......... .......... D.h.I1 .......... .......... .......... .......... .......... D.h.I2 .......... .......... .......... .......... .......... Sr.me.I2 .......... .......... .......... .......... .......... E.c.I4 .......... .......... .......... .......... .......... S.f.I1 .......... .......... .......... .......... .......... C.sp.I1 .......... .......... .......... .......... ..MSNTSLKT G.v.I1 .......... .......... .......... .......... .......... T.sp.I1 .......... ...LVMKKAE ILKRRLGNPK PFLSVAWDTT DMLDQICVNP N.sp.I4 .......... .......... .......... MTWIVEVQVA MYTSKTSFKT B.a.I1 .......... .......... .......... .......MNT VNMKSAVSPQ B.c.I1 .......... .......... .......... .......... ...MNTSERA E.c.I5 .......... .......... .......... .......MTE QATTCKGASL A.v.I1 .......... .......... .......... ........MS ASEKEVPASS B.t.I1 .......... .......... .......... ......MNEI KTSCASTDRK B.me.I2 .......... .......... .......... ........MN TSLRASAHVS A.v.I3 .......... .......... .......... .MTEPARHAQ AATPRSSGAP B.f.I1 .......... .......... .......... .......... ....MSMRQA B.f.I2 .......... .......... .......... .......... ....MSMRQA Ma.sp.I1 .......... .......... .......... ....MQIKEA RGDNSPRSLC R.m.I1 .......... .......... .......... .......... .......... Tr.e.I8 .......... .......... .......... .....AEVKD RFSNEIGAKE P.p.I2 .......... .......... .......... .MTVIGSAAK TDAIGTGAPS M.a.I1-1 .......... ........MP TCHWSRKQQG LLIMNVRKPE ITSVTDLTDK M.a.I1-2 .......... ........MP TCHWSRKQ.G LLIMNVREPE ITSVTDLTDK M.a.I1-3 .......... ........MP TCHWSRKQQG LLIMNVRKPE ITSVTDLTDK M.m.I1-1 .......... .......... .......... ...MNVREPE ITSVTDLTDK M.m.I1-2 .......... .......... .......... ...MNVREPE ITSVTDLTDK X.f.I1 .......... .......... .......... ....ERKQMT TQAACAGALS R.r.I1 .......... .......... .......... .....MTAIG AKAANAGASS P.p.I1 .......... .......... .......... .....MPPVG VTVSLVAVMQ Sr.me.I3 .......... .......... .......... .......... .....MQEAR S.p.I1 .......... .......... .......... .......... .......... S.ag.I1 .......... .......... .......... .......... .......... A.v.I2 .......... .......... .......... .........M LETMSMSEAM A.v.I4 .......... .......... .......... .......... .....MSRAM D.h.I3 .......... .......... .......... .......... .......... N.e.I1 .......... .......... .......... .......... .......... N.e.I2 .......... .......... .......... .......... .......... G.s.I1 .......... .......... .......... .......... .......... O.i.I1 .......... .......... .......... .......... .......... P.p.I3 .......... .......... .......... .....MPPVG VAVSLVTVMQ B.h.I1 .......... .......... .......... .......... .......... B.t.I3 .......... .......... .......... .......... MKERMQKTSA A.g.I1 .......... .......... .......... .......... .......... S.ma.I2 .......... .......... .......... .......... .......... M.sp.I1 .......... .......... .......... .......... .....MSLLD C.a.I1 .......... .......... .......... ......MKNS KEMQKLQTTS P.a.I1 .......... .......... .......... .....MPPVG VAVSLVTVMQ P.a.I2 .......... .......... .......... .......... ...MGCRTAE S.t.I1 .......... .......... .......... .......... .......... B.me.I1 .......... .......... .......... .......... .......... C.d.I1 .......... .......... .......... .......... .......... B.a.I2 .......... .......... .......... .......... ........MN En.fm.I1 .......... .......... .......... .......... ....SLMPKN E.f.I3 .......... .......... .......... .......... ....MPVLTS E.f.I4 .......... .......... .......... .......... .......... E.f.I1 .......... .......... .......... .......... ..MERDKTMT E.f.I2 .......... .......... .......... .......... ......MNQN N.p.I1 .......... .......... .......... .......... ..MIRHSSYL Th.e.I1 .......... .......... .......... .......MTV DQTTGAVTNQ Tr.e.I2 .......... ......MNKA KTLKRCLGNP KPFLSVAWDT NDIPNPCSVN Tr.e.I3 .......... .......... .......... .......... ...MTKTRKN Tr.e.I4 .......... ......MEKA KTLKRRMDKP ESFLSVAWDT DDIPDKICVN Tr.e.I5 .......... .......... .......... .......... .MSNTRETTT Tr.e.I6 .......... ......MNKA KTLKRNLGNP QPFLSVAWDT EDIPSQVSIN Tr.e.I7 .......... .......... .......... .......... .MSNTSLKTG Tr.e.I9 .......... .......... .......... .......... .......... Sr.me.I1 .......... .......... .......... .......... .......... B.j.I1 .......... .......... .......... .......... .......... R.e.I1 .......... .......... .......... .......... .......... E.c.I1 .......... .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 .......... .......... .......... .......... .......... P.l.I2 .......... .......... .......... .......MSA RVPMRGTGAE M.a.I5-1 .......... .......... .......... .......... .......... M.a.I5-2 .......... .......... .......... .......... .......... M.a.I5-3 .......... .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 .......... .........M HDTEKSDSGI VAEKPTNKAG LLAAEWAEPR P.l.I1 ........ .......... .......... .......... .........MEG Sr.me.I4 .......... .......... .......GRE SDWFIVPMKP SKKTRRAEGR S.ma.I1 .......... .......... MMYGEEKSDS LIVAAKQANN PKGAESVERR N.sp.I1 .......... .......... .....MRFVQ KIFKGVENVM TTELNPVDKW N.sp.I2 MDTSIFHVGE VRHGNLSSWV GCSVIAARYS EKHLAEKSMI RHSVKASESW N.sp.I3 .......... .......... .......... ........MV RHSAKASELW Ma.sp.I2 .......... .......... .......... .......... .......... S.ag.I2 .......... .......... .......... .......... ..........

N.a.I2 .......... .......... .......... .......... .......... N.a.I1 .......... ....MLPDTI ERAVRSLPTV IRSGRKVNGL YRLLKSPL.L L.l.I1 .......... ....MKPTMA ILERISKNSQ ENIDEVFTRL YRYLLRPD.I B.t.I2 .......... ....MRNPEN VLNSLSKHSG .NLNYKFERL YRVLFNEE.M OYPI1 ......MINM STTVSDETKL SRTLNKILYC STNNYPLKRE LQQGMNNFHN D.h.I1 .......... ...MRSPITV LKSLTEKSK. ..DESYKFQR LYRNLYNPEF D.h.I2 .......... ...MRSPQIV LENLQRQSQK ...QDYRFER LYRNLYNPDF Sr.me.I2 ......MDTD HRTDKVWVLG IQRKLYQWSK ANPDDQWRDM WGWLTDLR.V E.c.I4 .......... .......... MQRKLATWAA TDPSLRIQRL LRLITQPE.W S.f.I1 .......... .......... MQRKLATWAA TDPSLRIQRL LRLITQPE.W C.sp.I1 TAEWNTIPWR KLERSVYKLQ KRIYQASQRG DTKAVRKLQK TLMRSWSG.K G.v.I1 MVEWNSLNWR QIQRRVFKLQ TRIFKASQRG DFKAVRKLQK LLIRSWSA.R T.sp.I1 NLKWRDIDWK KVERYVFKLQ HLIYKASSRG KIRKMRKYQK LLTKSYDA.R N.sp.I4 TVEWNAIPWQ KLERKVFKLQ KRIYKASQRG DVKAVRQLQK TLLHSWSA.K B.a.I1 VTQWNSIQWK EIENYVKKLR QRIYRAEQFG NKRKVRKLQR LMLRSKAN.L B.c.I1 SAHVSYTNWK AVQMYVTKLR QRIYRAEQLQ QQRKVRKLQR LLMRSEAN.L E.c.I5 LNGDSWHSIN WRQCYREVRR LQARIVKATR EGKHGKVKSL QWILTHSFSG A.v.I1 LPASSWHTID WATSHRRVRG LQVRIAKAAK NRQWRQVKTL QRMLVRSFAA B.t.I1 WSTWESIDWN KCVIAVNKLQ ARIVKAQKAG KHGRVKSLQW VLTHSFYA.. B.me.I2 HKDWYSIDWS IIQKYVAKLR QRIYRAEQQK QRRKVRKLQR LLLRSKAN.L A.v.I3 SHAKSNWPQS WCRIESDVKR LQVRIAKATR EGRWGKVQAL QRLLTRSYSG B.f.I1 MRQMPVQTGR AGVTRGEAAP MPVSDEACCP RHESGDAGSA LLAAALTREN B.f.I2 MRQMPAQAGR AGVARGEAAR VPVSDEACGP RREPENTGSA LLQAALTREN Ma.sp.I1 SPGFKNWNSI EWKVHRNVSR LQARIVKAEK EGRIGKVKAL QIILTKSLAA R.m.I1 .......... .......... MQIRIAKATQ ERDWRRVKAL QRSLTRSFSA Tr.e.I8 PLKEWLDINW KTIKKCVRNL RRRIYRAKQN SQWNKVRSLM KLMLRSYSNL P.p.I2 HAERMWLQAN WGLIKEDVKR LQARIAKATM EGRWGKVKAL QHLLTRSHNG M.a.I1-1 ELTQQWKSID WKRVKEVVNN LQSRIASAAK NGKWITVNKL SRLLTRSLYA M.a.I1-2 ELTQQWKSID WKRVKEVVNN LQSRIASAAN NGKWKTVNKL SRLLTRSFYA M.a.I1-3 ELTQQWKSID WKRVKEVVNN LQSRIASAAK NGKWITVNKL SRLLTRSLYA M.m.I1-1 ELTQQWKIID WKRVKEVVNN LQSRIASAAK SGNWKTVNKL SRLLTRSFYA M.m.I1-2 ELTQQWKIID WKRVKEVVNN LQSRIASAAK SGNWKTVNKL SRLLTRSFYA X.f.I1 GDSGGWHCID WANCHREVRR LQTRIVKATQ EGRWGKVKAL QWLLTHSFSG R.r.I1 HGGQICDQTD WSQIEATVKR LQVRIAKATR ECRWGKVKAL QRLLTRSHSG P.p.I1 KFPTAETIIL SPGQKPRMMP DSAKVSMASV AWTSAKSGTL MERVLAPA.N Sr.me.I3 HQMPARAGRS GGRQGEALSE PGSDEATCPR CDAQSTGPGL LEAALARE.N S.p.I1 .......... .......... .......... ......MSKL LDKILSRE.N S.ag.I1 .......... .......... .....MQTTK KERNTHMSEL LDKISSRN.N A.v.I2 HQKPACAGRH AAGQGEAPAK VSRGEAEGPR HEMEGTGSAL LEAALTRE.N A.v.I4 HQMPVETGRV MQCRGEAPSQ PSSDEAHLPR QGSEDAGRRL LEQVVAKE.N D.h.I3 .......... .......... MPLKMIETDN TNTNEPNEEL FEQILSSE.N N.e.I1 .......... .......... ...HRALNQD DDHNQDGQDL LEAVLARD.N N.e.I2 .......... .......... .......... .......... ...MLARD.N G.s.I1 .......... .......... .....MPVER VIDRPTPEEH LLERILATEN O.i.I1 .......... .......... .......... ........ML MNQILSRD.N P.p.I3 KFPTAETVIP SSGQKPRVTP DSAKVSTASV TWTNAEPDTL MERVLAPA.N B.h.I1 .......... .......... .......... .........M LERILSRE.N B.t.I3 QAHDFPQRAR TESEWYEGVQ TFMWMTEDNI VEVPFDKEHL LEIILSPS.N A.g.I1 .......... .......... .......... .MKPAFSNDL FEHVLQED.N S.ma.I2 ......MNLN SHRSPCCDSD EQRSTVNNTS NEYNQIDHDL MAKVLSNH.N M.sp.I1 EWERDSLPVK GTDVFCKRTG KVGHQWLSAC EEERALTRGL MYKVCDLS.N C.a.I1 YKEGWSCEIR VELQNSTRAH SISTAFDRRK DDGKLYETNL LERILDRQ.N P.a.I1 KFPTAETVIP NPGQKPRVMP DSAKVPAASA TWTNAEPDTL MERVLAPA.N P.a.I2 ASPQGKAVPR HGGRNPRMPA DSAQTPMASV TWTKAEPNTL MERVLSPA.N S.t.I1 .......... .......... .......... .MQPAFNNDL FQQLLEPE.N B.me.I1 .....MLKRK KLRHNEYYDM QYNFDSLYAQ SANGQNFYGL LDLMQSDD.N C.d.I1 MTVKVSNKKA LRFNEYYDTQ KIQDELYQLS AEGSHVFRDL MSYITQEE.N B.a.I2 GNSKSAPKGK KLRHNEYYGI QPVLDNLYQK ATKGNSFKNL MSIIISDE.N En.fm.I1 KNETLCVLED LRHAEYYEMQ NTFDDLYAKS KNGD.IFTHL MDIILSRE.N E.f.I3 GQQERKSKQR KIRNSEYYDM EGTFDRLYAE SKKDKTFNHL MEIIESEE.N E.f.I4 ..MEVPRLNT KIRYWEYYDL QETFDQLFTQ SKNGKKFYQL YELIISEN.N E.f.I1 NTKGISLKNK QLRHAEYYDM TETFDELHAM SVAKSNFKNL MKFIIDDN.N E.f.I2 LLEKTPKNNK LRYAEYYGMI EIYDELFNKS NEGK.IFKNL MGIIISTD.N N.p.I1 TSESWNKFPW KKIQKNVFRL QRRIYKAMKE GNLVKAKSLQ KLILKSTSAK Th.e.I1 TEISWHSINW AKANREVKRL QVRIAKAVKE GRWGKVKALQ .WLLTHSFYG Tr.e.I2 PNFKWKDINW KKVEKYVFKL QKLIYRASSR GEIRKVRKYQ KLLTKSYYAR Tr.e.I3 PMVVWTPVNW RKLKRVVYKL QKRIYQAAQR GDVKAVRKLQ KTLLNSWSAK Tr.e.I4 PNLKWRDIDW KKVEKNVFKL QKLIYRASSR GEIRKMRKYQ KLLIKSHDAL Tr.e.I5 VEMEWHKVNW KAVNRAIFRL QKRIYKASHN GDTKAVKKLQ KLLVKSKSAR Tr.e.I6 LTLKWRDIDW RRAMKNVFKL QKLIYRASSC GKIRKMPRYQ KLLTKSYYPL Tr.e.I7 EWKEWREINW TKVERRVFKL QKRIYRASQR GDVIAVRKLQ KMLIKSWYGR Tr.e.I9 ..MNKAEILK RKLDNPRPFS SVAWDAYDIP SQACVNPNLK WKDINWKKVE Sr.me.I1 .......... .......... .......... ..MTSESTTD KPFRIEKR.R B.j.I1 .......... .......... .......... ......MKSG KPLPITKR.M R.e.I1 .......... SSCNGNGAKG RRYPADERGQ PAGMSGVKSA KPYNIANG.T E.c.I1 .......... ..MNVERRGN VGQSASQPNC KQEEAAGEQT KPFQVSKL.H E.c.I3 .......... .......... .......... .......MQR KSFEIPKA.L E.c.I2 .......... .......... .......... ......MTKT KAFNIDKS.L P.l.I2 QAVVALKDRN GSGAKGLPHC ADGTTATTGD KAGGRTAVKS AKPFPVSKRQ M.a.I5-1 .......... .......... .......... .......MDE TKPYEISKDI M.a.I5-2 .......... .......... .......... .......MDE TKPYEISKDI M.a.I5-3 .......... .......... .......... .......MDE TKPYEISKDI UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 PGTKGNAEQQ RMHRTQGRAR MTQSLDRVRT AARLRKKDRF TALFHHIN.V P.l.I1 RLPTKGNSQQ CARIRTQSRG NTTLRLLAVR KAAKRDRKQQ FTHLFHHISE Sr.me.I4 DRPERIPQGE ARIRTQSRVI LMPNLERVNA AAKQAVQTRF TSLLHHVD.Q S.ma.I1 SGAKGNAEQP HMRRTQSRES MSQRLSRVRE AAKQRKKERF TALFHLLT.V N.sp.I1 KSIPWRKLRK IVFRLQVRIF KAQKNGNTRL VRKLQKLLLS SKAAKLLA.I N.sp.I2 KNLPWKKFRR DLFRLQRRVF KAVQAGNKRK ARFLQKLILK SKAGRFLA.I N.sp.I3 KSLPWKKFRA NLFRLQKRVF KAVRVGDKRK ARSLQKLILK SKAARFLA.I Ma.sp.I2 .........M IKTSIRLQDQ DLRRKIYRKA KIDKSWRFWG LYHHVCKPET S.ag.I2 ......MIAQ KAINIFEKVQ VFQRKIYLST KADNKRKFGV LYDKVYRKDI

Domain 0 |------------------------------| N.a.I2 .......MPP IGGRMT.... ...PGIDGKT F.EDFGP... ....DRLAPL N.a.I1 WEHAYQRIAP NKGAMT.... ...PGVDGQT F.DGFSP... ....DKVRSI L.l.I1 YYVAYQNLYS NKGASTKGIL DDT..ADGF. .......... ..SEEKIKKI B.t.I2 FYVAYQNIYS KTGNMT.... ...AGADGK. .......TID GMSIDRVEQL OYPI1 TLTAFNKIAA NKGAGT.... ...PGIDGNS I.DSL..... ..NLKKLERY D.h.I1 YWLAYQNIYA NKGSMT.... ...PGMDGTT I.SGI..... ..NEERIRQI D.h.I2 YLLAYQKLYA NNGAMT.... ...PGVDRTT L.DGT..... ..GMERIESL Sr.me.I2 LRHAWQRVAS NKGGRT.... ...AGVDGMT V.GRIRNR.. .SEHRFLVDL E.c.I4 LAEAARITLS SKGAHT.... ...PGVDGVN K.TMLQAR.. ..LAVELQIL S.f.I1 LAEAARITLS SKGAHT.... ...PGVDGVN K.TMLQAR.. ..LAVELQIL C.sp.I1 ALAVRKVTQD NQGKKA.... ...AGIDGVK S.LKPSAR.. .....LTLVM G.v.I1 CLAVRRVTQD NQGKKT.... ...AGVDGVK S.LTPKAR.. .....LALTK T.sp.I1 LLAVRRVTQE NQGKKT.... ...VGIDGIK S.LPPMQR.. .....FNLVE N.sp.I4 CLAVRRVTQD NRGKKT.... ...AGVDGRK N.LSPKAR.. .....LILVQ B.a.I1 LLSIKRVTQI NQGKRT.... ...AGIDGIT T.NTPEDR.. ....VKLFHL B.c.I1 LLSIRRVTQQ NKGKRT.... ...AGVDEHT A.LSRRER.. ....NLLYEQ E.c.I5 RAVAVRRVTE NSGKRT.... ...PGVDGQT W.SSPEVK.. .......FLA A.v.I1 KALAVKRVTE NRGRRT.... ...PGVDGET W.STPESK.. .......WKA B.t.I1 KALAVKRVTS NSGSDT.... ...AGVDKVK W.STPNAR.. .......FKA B.me.I2 LLSIRRVTQQ NNGKRT.... ...PGVDGYT A.SKPNER.. ....IKLYQQ A.v.I3 KMLAVKRVTE NRGKKT.... ...PGIDGKI W.STPVAK.. .......SKG B.f.I1 LKRAFKRVRA NKGA...... ...AGVDGLD I.GQTARH.. ..LVTAWPVI B.f.I2 LQRALKRVRA NKGA...... ...AGVDGLD I.DQTARH.. ..LATAWPGI Ma.sp.I1 RALAVKRVTE NRGKNT.... ...PGVDGSL W.KTPGSK.. .......AKA R.m.I1 KASAVRRVTE NQGKRT.... ...AGVDREL W.DSPEVR.. .......WVA Tr.e.I8 LLSVRRVTQE NQGIRR.... ...MGRDAQT A.KTSVEK.. ......VKLV P.p.I2 KMLAVKRVTE NRGKRT.... ...PGVDGKI W.ATPAAK.. .......SSG M.a.I1-1 KLLSVRKVTT NKGSRT.... ...PGIDGII W.SSSADK.. .......MRS M.a.I1-2 KLLSIRKVTT NKGSRT.... ...PGIDGII W.SSSADK.. .......MRS M.a.I1-3 KLLSVRKVTT NKGSRT.... ...PGIDGII W.SSSADK.. .......MRS M.m.I1-1 KLLSIRKVTT NKGSRT.... ...PGIDGII W.SSSADK.. .......MRA M.m.I1-2 KLLSIRKVTT NKGSRT.... ...PGIDGII W.SSSADK.. .......MRA X.f.I1 KALAVRRVTE NQGKKT.... ...PGVDKVV W.GTPEKK.. .......ENA R.r.I1 KMLAVKRVTE NRGKKT.... ...PGVDGEI W.TTPVAR.. .......WKG P.p.I1 LRRAYQRVVS NKGA...... ...PGADGMT V.ADLAGH.. ..VKQYWPIL Sr.me.I3 LQRAWKRVKA NKGA...... ...AGADGLS I.EATAAH.. ..LRTSWPDI S.p.I1 MLEAYNQVKS NKGS...... ...AGIDGMT I.EEMDNY.. ..LRQNWRLT S.ag.I1 MLEAYKQVKS NKGS...... ...AGIDGVT I.EQMDDY.. ..LHQNWRET A.v.I2 LRQAFKRVRA NRGS...... ...AGVDGLD I.DQTARK.. ..LVTEWPAI A.v.I4 MQRAWKRVKA NKGA...... ...AGVDGLD I.DQTESH.. ..LRQVWPSI D.h.I3 LNQAYRQVKK NKGA...... ...GGIDGMQ V.DELLPY.. ..LRDHKDEL N.e.I1 LARAWRRVKS NRGA...... ...PGIDGVT T.AEWPEH.. ..ARAHWPAT N.e.I2 LARAWRRVKS NRGA...... ...PGIDGVT T.AEWPEH.. ..ARAHWPAT G.s.I1 MDLAWKRVRA NKGA...... ...PGVDGVT I.DAFPER.. ..FRPLWGDI O.i.I1 LILALKRVER NKGS...... ...HGIDEMS V.KFLRRH.. ..LYDNWDSL P.p.I3 LRRAYQRVVS NKGA...... ...PGADGIT V.ADLAGY.. ..VKQYWPTL B.h.I1 LIQALERVEK NKGS...... ...YGVDEMD V.KSLRLH.. ..LHENWTSI B.t.I3 LNKAYKAVVR NNGS...... ...GGIDKMS C.EQLLSW.. ..LKANKDEL A.g.I1 LSAAWKRVRA NKGA...... ...AGIDGMT I.DEFPAW.. .VRSGNWKAL S.ma.I2 ISAAWQHVKR NKGA...... ...AGIDNMS I.EEFNDF.. ..AKLHWLGI M.sp.I1 LTASLKQVVK NGGS...... ...PGVDGMQ V.KELRYW.. ..FSNNHQKL C.a.I1 MNLAYKRVKS NKGS...... ...HGVDGMK V.DELLQY.. ..LKQNGKTL P.a.I1 LRRAYQRVVS NKGA...... ...PGADGMT V.ADLAGY.. ..VKQYWPTL P.a.I2 LRRAYRRVVN NRGA...... ...PGADGLS V.DELAGY.. ..LKQYWPSL S.t.I1 LHRAWRQVKA NKGA...... ...AGIDGMT I.EAFPLW.. .MQQGGWQLC B.me.I1 IRLAYRNIKR NTGSKT.... ...AGDDGLT I.EDINR... ..LSVSEVVS C.d.I1 ILLAYRNIKS NKGSKT.... ...AGTNKRT I.IDVGE... ..ENPYQLVQ B.a.I2 ILLAYRNIKG NKGSRT.... ...AACDNVN I.KNIEG... ..MEQSYFLN En.fm.I1 ILLAYRNIKA NAGSKT.... ...AGTDGTI I.KDIGKL.P AETVVKKVRY E.f.I3 IKLAYRTIKK NTGSDT.... ...SGVDKRT I.ADLAKL.. ...SEEEYVR E.f.I4 ILLAYRTIKA NKGSST.... ...PGTDSFT I.DNYKEM.. ...NQAEFIH E.f.I1 IFLAYRNIKK NKGSAT.... ...AGYDGVT I.KDIEKL.. ...ACGDFLT E.f.I2 ILLAYRTIKR NGGSTT.... ...KGIDGVT V.KDIEKL.. ...SQSEFIG N.p.I1 LLAIRQVTQL NRGKRT.... ...AGIDGKK H.TQTERM.. ......QLLQ Th.e.I1 KALAVKRVTD NSGSKT.... ...PGVDGIT W.STQEQK.. .......TQA Tr.e.I2 LLAVRRITQD NQGKKT.... ...AGIDGIK N.LPSMQR.. .......FNL Tr.e.I3 MLATRRVIQD NKGQKT.... ...AGIDGKK S.LTLKER.. ........VN Tr.e.I4 LLAVRNVTQD NQGKKT.... ...AGIDGIK N.LPPMQR.. .......LHL Tr.e.I5 LLAVRKVTQD NTGKKT.... ...PGIDGVG E.LAPLQK.. ........LE Tr.e.I6 LLTVRWVRQD NQVKNT.... ...VGVDGIK N.LPPMQR.. .......FNF Tr.e.I7 LLAVRRFSQI NQGEKI.... IEVGGVQLLS P.DKCFA... .......... Tr.e.I9 KYVFKLQKLI YRASSR.... ...GEIRKMR KYQKLLTK.. .......SYY Sr.me.I1 VYEAYKAVKA NRGA...... ...AGVDGQT L.EIFEKD.. ..LAANLYKI B.j.I1 VWEAYKLVKK GK.A...... ...AGVDGQS L.EDFAGD.. ..LENHRYRL R.e.I1 VWEAYQQVKA NRGA...... ...AGIDDEA I.AEFEQN.. ..LSKNLYKL E.c.I1 VVEAYRRVKA NAGA...... ...AGVDNQT L.KDFERD.. ..LKGNLYKI E.c.I3 VWASYLDVRR NKGA...... ...PGCDGQT L.KMFDQQ.. ..RDGNLYKI E.c.I2 VVSAYRRVKT SAGA...... ...AGIDKQS L.ADFDKR.. ..LVDNLYKI P.l.I2 VWDAYKRVKA NRGA...... ...AGIDGQT L.AGFDEN.. ..VADNLYKL M.a.I5-1 VQEAFQRVKA NKGA...... ...AGVDDEN I.AAFESD.. ..LTNNLYKI M.a.I5-2 VQEAFQRVKA NKGA...... ...AGVDDEN I.AAFESD.. ..LTNNLYKI M.a.I5-3 VQEAFQRVKA NKGA...... ...AGVDDEN I.AAFESD.. ..LTNNLYKI UMB .......... .......... ...MGVDHVS M.EAIASN.. ..PRKYLYPL A.v.I5 .......... .......... ........MS W.REYEED.. ..LHQRVGKL B.j.I2 DTLRAAFFAL RRRAA..... ...PGVDGMT W.QDYEED.. ..LEPRLADL P.l.I1 ELLCQSFQQL KRQSA..... ...PGCEGIT W.ENAEN... ..LQNNLHAL Sr.me.I4 AALHRAFRRQ KRQAS..... ...AGVDGMT V.AKYEER.. ..LEQNLHDL S.ma.I1 EALEAAFLSL SRKAA..... ...AGVDGIR W.MDYAGN.. ..MKNNITDL N.sp.I1 RQVTQ..LNT ..GRKT.... ...AGVDGKK A.LEPSQR.. .....LALYE N.sp.I2 RQISQ..LNA ..GKKT.... ...AGIDGVK S.LDFNGR.. .....FELEI N.sp.I3 RQVTQ..LNA ..GKNT.... ...AGIDGKT A.LTHEER.. .......FNL Ma.sp.I2 LNTAYEMARK NKGA...... ...PGIDGVT F.EAIEES.. .GVEQFLGEV S.ag.I2 LKVAWFYVKR NKGS...... ...AGIDDFT I.EEIEAY.. .GVQKFLDEI

Domain 1 Domain 2 |-------||------------------------------ N.a.I2 IASVATGAYK PKPVRRVFIP KG.KG.KRRP LGIPTRDDRL VQEVARQLLE N.a.I1 IERLANGTYR PQPARRVYIP KA.NG.QKRP LGVPTTEDKL VQEVVRTILE L.l.I1 IQSLKDGTYY PQPVRRMYIA KK.NSKKMRP LGIPTFTDKL IQEAVRIILE B.t.I2 IGSLKNETYQ PNPSKRTYIP KK.NG.KKRP LGIPSFDDKL VQEVVRMILE OYPI1 HKEYINNKYN PKPVKRIFIS KD.ND.KVRP LGIPTIKDRI VQKSLEQLLT D.h.I1 IASLKDQSYQ PHPARRVYIE KK.NSQKKRP LGISTANDKL VQEVVRMILE D.h.I2 IQSLKNRSYQ PQPARRRYIP KK.SGKGQRP LGIQAANDKL VQEVVRMLLE Sr.me.I2 QADLRSGAYR PSPARRKLIP KAGKPGQFRP LGIPTIRDRV VQGAAKILLE E.c.I4 RDELLSGHYQ PLPARRVYIP KS.NG.KLRP LGIP.LRDRI VQRAMLMAME S.f.I1 RDELLSXHYQ PLPARRVYIP KS.NG.KLRP LGIPALRDRI VQRAMLMAME C.sp.I1 N..MKLNH.K VKATRRVWIP KPGNV.EKRP LGIPTMQDRA TQSLVKLALE G.v.I1 N..LRISE.K AKPMRRVWIA KPGTQ.EKRP LGIPTMTDRA RQALLTLALE T.sp.I1 M..LKSRYLK ASPTRRVWIP KPGKE.EKRP LSIPTLYDRA LQALVKLGRS N.sp.I4 S..MKLGD.K ASPTRRVWIP KPGSSGEKRP LSIPTLYDRA LQSLVKLALE B.a.I1 LKGYSVRNIK AFPVKRAYIP KK.NG.KKRP LGIPVIKDRI FQNMVKNALE B.c.I1 LKKLNTLQHR PKPAKRIYIV KK.NG.KLRP LGIPTIKDRV YQNIVRNALE E.c.I5 INLLKRRGYK PQPLKRVYIP KS.NG.KSRP LGIPTMKDRA MQALYLLALE A.v.I1 IFRLQRTGYR PRPLRRVYIP KA.NG.QRRP LGIPTMLDRA MQALYLLALE B.t.I1 IGELKRRGYK PQPLKRVNIK KS.NG.KLRP LGIPTMKDRA MQALYLLALE B.me.I2 LVKCNVFRHR PKPAKRTFIP KK.NG.KLRP LGIPTMRDRV YQNVVKNALE A.v.I3 ASALKQRGYR PQPLRRLYIP KS.DG.KERP LGIPTMRDRA MQALWKLALE B.f.I1 REQLLKGTYR PDPVRRVTIP KP.DG.GERE LGIPTVTDRL IQQALLQVLQ B.f.I2 REHLLRGTYR PSPVRRVAIP KP.DG.GERE LGIPTVTDRL IQQALLQVLQ Ma.sp.I1 VQHLRRKGYK ASALKRVYIP KA.NG.KKRP LGIPTMRDRA MQALYQMALD R.m.I1 IGRLRRRGYR PMPLRRVFIP KA.NG.KERP LGIPTMLDRA MQALYLLALE Tr.e.I8 KEMLTYRLWQ AKPAKRVYIP KA.NR.QQGP LGIPTVKNRV AQAVVKNGLE P.p.I2 MESMRHRSYR ALPLRRIYIP KS.NG.QKRP LGIPRMLCRS MQALWKLALE M.a.I1-1 ALQLTNKGYR AKPLTRKYIR KK.NG.KLRP LSIPTMYDRA MQTLHSLVLG M.a.I1-2 ALQLTNKGYR AKPLTRKYIR KK.NG.KLIR LSIPTMYDRA IQTLHSLMLG M.a.I1-3 ALQLTNKGYR AKPLTRKYIR KK.NG.KLRP LSIPTMYDRA MQTLHSLVLG M.m.I1-1 ALQLTNKGYR AKPLTRKYIR KK.SG.KLRP LSIPTMYDRA MQTLHSLVLG M.m.I1-2 ALQLTNKGYR AKPLTRKYIR KK.SG.KLRP LSIPTMYDRA MQTLHSLVLG X.f.I1 VDELRRHGHK ARPLRRVYIP KS.NG.KLRP LGIPTMRDRA MQALHLLSLL R.r.I1 VMSLRHHGYR TMPLRRVYIP KS.NG.KKRP LGIPRMLCRA MQALWKLALE P.p.I1 KARLMAGEYH PQAVRAVEIP KP.QG.GTRQ LGIPSVVDRL IQQALQQQLT Sr.me.I3 RERVLAGTYR PMPVRRVTIP KP.DG.GERE LGIPTVTDRL IQQALLQVLQ S.p.I1 KELIKQRKYK PQPVLKVEIP KP.DG.GIRQ LGIPTVMDRM IQQAIVQVMS S.ag.I1 KKLIKERSYK PQPVLRVEIP KP.NG.GVRN LGIPTAMDRM IQQAIVQVLS A.v.I2 REQLLRGTYR PSPVRRVMIP KP.DG.SQRE LGIPTVTDRL IQQALLQVLQ A.v.I4 RQQLLMGTYQ PLSVRRVCIP KP.DG.SERE LGIPSVTDRL IQQALLQVLQ D.h.I3 LESLREGTYR PTPVRRVEIP KE.NG.KTRK LGIPTVVDRL IQQAIAQILS N.e.I1 REQIEAGRYR PQPVRRVDIP KP.DG.GQRQ LGIPTVTDRV IQQAIAQVLI N.e.I2 REQIEAGRYR PQPVRRVDIP KP.DG.GQRQ LGIPTVTDRV IQQAIAQVLI G.s.I1 RASLATGTYQ PQPVLRVEIP KP.TG.GTRP LGIPTVLDRL IQQATAQVLT O.i.I1 RENLRKGTYT PSPVRRVEIP KP.SG.GVRM LGIPTVTDRF IQQAIAQVLH P.p.I3 KARLLAGEYH PQAVRAVEIP KP.QG.GTRQ LGIPSVVDRL IQQALQQQLT B.h.I1 RNEIIEGSYF PKPVRRVEIP KP.NG.GVRK LGIPTVMDRF LQQAIAQILT B.t.I3 IISLQSGTYR PNPVRRVEIP KD.NG.KKRL LGIPTVVDRL VQQAINQVLT A.g.I1 KQQLVTGCYQ PSPVRRVEIA KP.DG.GTRQ LGIPTVTDRV IQQAITQVLT S.ma.I2 KQQLLNGSYQ PLPVKRVMIP KP.DG.GERM LGIPAVIDRV IQQAIAQVIS M.sp.I1 IEQLKEGNYR PMTIKGQEIP KP.GG.GVRQ LGIPTVQDRL VQQAIAQQLS C.a.I1 IASIFNGKYC PKAVRRVEIP KP.DG.GIRL LGIPTVVDRT IQQAISQVLT P.a.I1 KARLLAGEYH PQAVRAVEIP KP.QG.GTRQ LGIPSVVDRL IQQALQQQLT P.a.I2 RERLQTGEYQ PYGVRAVNIP KP.DG.GVRT LGIPSVLDRL IQQALLQQLT S.t.I1 KSQLERGEYQ PSAVRRVEID KP.DG.GKRK LGIPNVIDRV IQQAIAQILT B.me.I1 TIQRMFEYYT PQAVRRVFIP KA.NG.KTRP LGIPTIWDRL FQQCILQVLE C.d.I1 YVQNRFNNFQ PHSIRRVEIP KP.NG.KTRP LGIPTIEDRL VQQCIKQILE B.a.I2 EVKRRFQNYQ PQKVRRKEIS KP.NG.QTRP LGIPAMWDRI IQQCILQVME En.fm.I1 IVAGSPHGYR PKPVRRKEIP KP.NG.KTRP LGIPCMWDRL IQQCIKQVLE E.f.I3 LIRKQFSNYH PGPVRRVEIP KP.NG.KTRP LGIPTIVDRI VQQCILQVME E.f.I4 LILSQLENYK PKSIKRVMIP KP.NG.EKRP LGIPCMIDRI IQQMFKQVLE E.f.I1 IIKRRFKDYR PRKVKRVEIP KP.NG.KLRP LGIPSIWDRI VQQCILQILE E.f.I2 KVRNRFNFYK PRKVRRVEIP KP.NG.KTRP LGIPSIWDRI AQQCILQVLE N.p.I1 LLQHGAFEWK HQGLKEIPIP KK.NG.KVRI LKVPTISDRA WQCLAKLALE Th.e.I1 IKSLRRRGYK PQPLRRVYIP KA.NG.KQRP LGIPTMKDRA MQALYALALE Tr.e.I2 VDLLKRHRFK ASPTRRVWIP KP.GKDEKRP LGISTMYDRA LQALVKLGRS Tr.e.I3 LANNLVMSHK AKSTCRIWIP KP.GKTEKRP LGILTISERA KQGLVKMAIE Tr.e.I4 VDLLKSRDLK ASPTQKVSIP KT.GRNQKRR LGIHSLYDLG LQTLVKLGME Tr.e.I5 LARNLKLNGK AKPVRRIEIP KS.GRKKRKR LGVPTRLDRA KQALAKLALE Tr.e.I6 VYLLKSHSLK AILNPRVSIL KQ.GLNAKFS LSIPTMYDRA LQGSVKLSME Tr.e.I7 .......... ........LA KRLKLNSKVK PMISTVKDQP LQILVKMSLE Tr.e.I9 AEMLRSRHLK ASPTRRVWIP KP.GREEKRP LGIPTMYDRA LQALVKLGRS Sr.me.I1 WNRMSSGTYF PPPVRAVSIP KK.AG.GERV LGVPTVSDRI AQMVVKQMIE B.j.I1 WNRLVSGSYF PPPVRRVEIP KA.GG.GIRP LGIPTVADRI AQMVVKRCLE R.e.I1 WNRMPSGSYL PPPVKQVEIP KA.SG.GTRK LGVPTVADRV AQTVVKLVIE E.c.I1 WNRLSSGSWM PPPVRAVEIP KK.DG.SKRL LGIPTVSDRI AQMTVLVTFE E.c.I3 WNRLCSGTWF PPPVLEKRIP KS.NG.KERI LGIPTVSDRI AQGAIKLFME E.c.I2 WNRLSSGSYF PPAVKAVAIP KK.LG.GERI LGIPTVSDRI AQTVVKLAFE P.l.I2 WNRLASGSYM PQAVRRVEIP KA.DG.GVRP LGIPAVSDRI AQMVVKQVLE M.a.I5-1 WNRMSSGCYF PPSVKAIEIP KK.SG.GTRI LGIPTVLDRV AQMVTKIYLE M.a.I5-2 WNRMSSGCYF PPSVKAIEIP KK.SG.GTRI LGIPTVLDRV AQMVTKIYLE M.a.I5-3 WNRMSSGCYF PPSVKAIEIP KK.SG.GTRI LGIPTVLDRV AQMVTKIYLE UMB WNRLSSGSYF PPPVKLVPIP KG.DG.KERM LGIPTIIDRV AQEVIKAELE A.v.I5 HARLHRGAYR ATPSRRVYIP KA.DG.RQRP LGIASLEDKI VQQAVVTVLN B.j.I2 HKRVQRGTYR PQPSRRTYIP KA.DG.KQRP LAIAALEDKI VQGATVIVLN P.l.I1 HGRLHRGQYR PQPARQVMIL KE.DG.TERP LSILCLEDKI VQQAAVTVLN Sr.me.I4 CDRVHTGSLP AQPVRRVYIP KA.DG.GKRP LGVPALEDKI VQGAVAEVLS S.ma.I1 HRRLHQGSYR AQPGRRHYIP KA.DG.KQRP LGIASLEDKI VQYALVKILN N.sp.I1 VLVKNWKQWK HQPLKRVYIP KA.DG.TRRG LGIPTISDRA YQCLIKYALE N.sp.I2 TLKQSSGNWH HQELREIPIP KK.DG.TTRM LKIPTIADRC WQCLAKYALE N.sp.I3 EVLLRQQDWY HNKLRMIPIP KK.DG.SIRY LKIPTIADRA W.CLAKYALE Ma.sp.I2 RKELVSGSYR PLKNRRKAIP KG.DG.KERV LGIPSIRDRV VQGALKLILE S.ag.I2 EDQLRNKKYQ PKAVKRVYIP KA.NG.KKRP LGIPTVRDRV VQTAVKIVIE

Domain 2a ----||------------------| N.a.I2 RIYEPVFSKA SHGFRPGRSC HTALEHVKAV W......... ....TGVKWL N.a.I1 QIYEPLFSRH SHGFRPKRSC HTALESIRAI W......... ....TGVKWL L.l.I1 SIYEPVFEDV SHGFRPQRSC HTALKTIKRE F......... ....GGARWF B.t.I2 AIYEGSFEHT SHGFRPKRSC HTALIDIQKT F......... ....TAVKWF OYPI1 PYFENQFLEW SFGFRTKKSC LDAIKRVKQR F......... ....QGIDYI D.h.I1 SIFEPTFSDK SHGFRPVRSC QTALLQIQGN F......... ....TGVNWF D.h.I2 SIYEPTFLDS SHGFRPNRSC HTALARMQRS F......... ....NGVKWF Sr.me.I2 PIFEAQFWHV SYGFRPGRNT HGALEYIRRA ALPQKRDEDT RRNRLPYPWV E.c.I4 PIWESDFHTL SYGFRPERSV HHAIRTVKLQ L........T DCGETRGRWV S.f.I1 PIWESDFHTL SYGFRPERSV HHAIRTVKLQ L........T DCGETRGRWV C.sp.I1 PEWEAKFEPN SYGFRPGRNA HDAREAIFNS I......... ...RYSNKWV G.v.I1 PEWEARFEPN SYGFRPGRSC HDALQAIYNA I......... ...RQQSKFV T.sp.I1 PEWEALFEPN SYGLFRRSTY .DAIAAIYDS I......... ..NKKP.KYV N.sp.I4 PEWEARFEPN SFGFRPGRNA HDAMKAIFNT I......... ...KFKPKYV B.a.I1 PQWECRFESM SYGFRPKRSA HDAMANLFLK L......... .SRGTNRAWI B.c.I1 PQWEARFEAI SYGFRPKRST HDAIRSIFNR I......... .NGGTKKKWI E.c.I5 PVAEVTADQR SFGFRTGRST ADAIAQCFCV L......... .AQKTSAEWV A.v.I1 PVSETTADRN SYGFRPHRST ADAIEQLFVN L......... .GRKHSAQWV B.t.I1 PVSETTADSN SYGFRKERST GDAREQCFCV L......... .AKKASPEWI B.me.I2 PQWEVKFEPT SYGFRPKRST HDAISNLFNK L......... .NTNSKKKWV A.v.I3 PVAETRADPN SYGFRPERST ADAIAHGFTV L......... .AKRSSAEWI B.f.I1 PILDPTFSEH SYGFRPGRRA HDAVLAAQSY V......... ...QSGRRIV B.f.I2 PILDPSFSEH SHGFRPGRRA QDAVLAAQAY V......... ...QSGRRVV Ma.sp.I1 PVAECRADVN SYGFRRHRST ADAIEKCFAV L......... .SRKLAGRWV R.m.I1 PVSEGTSDPN SYGFRSNRST ADAMSQLFVN L......... .SRKVSASWI Tr.e.I8 PIWDAEFETN SYGFHPGRSC HDPLEQFWIR L......... ..QKGKDTWI P.p.I2 PVSESLADPN SYGFRPNRST ADAIEYCFIT L......... .AKRTSPVWV M.a.I1-1 PIESAIGDKT SFGFKPYRST KDAYAYLHIC L......... .SKKIAPEWI M.a.I1-2 PIESATGDKT SFGIKPYRST KDAYAYLHIC L......... .SKKIAPEWI M.a.I1-3 PIESAIGDKT SFGFKPYRST KDAYAYLHIC L......... .SKKIAPEWI M.m.I1-1 AIESAAGDKT SFGFKPYRST KDAYAYLHLC L......... .SKKVSPEWI M.m.I1-2 AIESAAGDKT SFGFKPYRST KDAYAYLHLC L......... .SKKVSPEWI X.f.I1 PVSETQADGC SYGFRPERSV ADAVDRCFRA L......... .NGQHSAQWI R.r.I1 PVTETLADPN SYGFRPKRST ADAIEQCFIT L......... .ARRKSATWV P.p.I1 PIFDPLFSDY SYGFRPGRSA HQAVGMARAH V......... ...ASGYRWC Sr.me.I3 PLLDPAFSEH SHGFRPGRSA HDAVLEAQSY V......... ...QSGRRIV S.p.I1 PICEPHFSDT SYGFRPNRSC EKAIMKLLEY L......... ...NDGYEWI S.ag.I1 PLCEKHFSEY SYGFRPNRSC ETAIVQLLEY L......... ...NDGYEWI A.v.I2 LLLDPSFSEH SYGFRPGRRA HDAVLAAQSF V......... ...QSGRRIV A.v.I4 PLIDPSFSEH SHGFRPGRRA WDAVLSAQRY A......... ...QEGYCIV D.h.I3 PIFEKQFSES SFGFRPNRSA HDVLKKSQSY I......... ...TAGYKYV N.e.I1 PIFDPGFSAS SFGFRPGRNA HQAIRQVQAH V......... ...KAGYRWA N.e.I2 PIFDPGFSAS SFGFRPGRNA HQAIRQVQAH V......... ...KAGYRWA G.s.I1 PIFDPEFSAS SFGFRPGRSA HNAVRQLREY L......... ...RQGYRIA O.i.I1 TIFDPSFSEH SYGFRPNRRG HDAVRKARGF I......... ...KEGYRWV P.p.I3 PIFDPLFSDY SYGFRPGRST HQAIEMARAH V......... ...TAGHRWC B.h.I1 QLYDPTFSER SFGFRPHRRG HNAVRQAKQW M......... ...KEGYRWV B.t.I3 LIYERQFSKT SYGFRPQRGC HDALRKAQKI V......... ...SEGYIYV A.g.I1 PIFDPEFSEH SFGFRPGRNG QQAVKQVQSI I......... ...KEGRRFA S.ma.I2 PYFEPQFSPH SYGYRPHKRA SQAVNHVQSC V......... ...KQGYKTA M.sp.I1 KRYDPTFSQY SYGFRKGRNA HQALRQAGAY V......... ...KEGFNYV C.a.I1 PIFEKTFSEN SYGFRPKRSA KQAIKKAKEY M......... ...EEGYKWV P.a.I1 PIFDPLFSDY SYGFRPGRST HQAIEMARAH V......... ...TAGHRWC P.a.I2 PLFEPLFSDF SYGFRPGRSA HQAIEMARAH V......... ...AAGYRWS S.t.I1 PLFDPFFSTN SFGFRPNRNA KQAVLQVRDI I......... ...KQKRKFA B.me.I1 PICEAKFYKH SYGFRPNRNT HHAKARFETL I......... ..NRACLYHC C.d.I1 PILEAKFHKH SYGFRPERSS HHAIAIFQQW T......... ...FKGFHYV B.a.I2 PICEAHFSNR SYGFRPNRSA EHALADASVR V......... ..NKQNLTYV En.fm.I1 PICEAKFSEN SYGFRPNRSV ENAIKATYNR L......... ..QISQLHYV E.f.I3 PICEAKFSEN SNGFRPNRSA ETAIAQCMRL I......... ..QVQHLYHV E.f.I4 PICEAKFYEH SYGFRPLRSA KHALGRIMYL I......... ..NISKMHYA E.f.I1 PICEAKFNKH SYGFRPNCST ENAIADCLAR I......... ..NQSKMNYV E.f.I2 PICEAKFNKH SYGFRPLRST DNAIADCLSN Q......... LKVICHIVGR N.p.I1 PAHEATFNER SYGFRPGRSA KDAQQYIRIN L........R SSCNGKDKRV Th.e.I1 PVAETTADRN SYGFRRGRCT ADAAGQCFLA L......... .ARAKSAEHV Tr.e.I2 PEWEAHFEPN SYGLRPGRST HDAIAAIYVS I......... ...NKKPKYV Tr.e.I3 PEWEAKFEPN IYGFRPGRSC MDAVEGIKAA I......... ...KQKSKYV Tr.e.I4 PEWEAHFETN TYGFRPGRST DDAIQAIYLS I......... ...NDEPKYV Tr.e.I5 PEWEAKFEAN SFGFRPGRST KDAIREICSD I......... ...NQGSYYV Tr.e.I6 PEWEKRFEPN SYGLGLGRST NDAIEIIFTS I.KNKSKYFL DVDISKCFDL Tr.e.I7 NQWEAKFELS SYGFKLPKSC QDAMKAIVNC V......... ...KFHPKYL Tr.e.I9 PEWEALFEPN SYGLFRRSTH DAIAAIYVSI N......... ....HKPKYV Sr.me.I1 PDLDSLFLPD SYGYRPGKSA LDAVGVTRQR C......... ....WKYDWV B.j.I1 PVLDGEFDPD SYGYRPGKSA HQAIEQARKR C......... ....WQHDWV R.e.I1 PGLDAIFHPD SYGYRPGRSA KQAVAITRER C......... ....WRYDWV E.c.I1 PLVERYFLND SYGYRHGKSA LDAIAVTRKR C......... ....WQYDWC E.c.I3 EKLDPIFHAD SYGYRPGKSA GDALKQCAIR C......... ....WRYSWI E.c.I2 PQVEPHFLAD SYGYRPNKSA LDAIGVTRKR C......... ....WYYDWV P.l.I2 PVLEPLFHAD SYGYRPGKSA HQAIAQARTR C......... ....WQFDWV M.a.I5-1 PQLEPLFHPD SYGYRPGKSA ADALAATRKR C......... ....WRYNWL M.a.I5-2 PQLEPLFHPD SYGYRPGKSA ADALAATRKR C......... ....WRYNWL M.a.I5-3 PQLEPLFHPD SYGYRPGKSA ADALAATRKR C......... ....WRYNWL UMB VIVEPRFHPS SFGYRPHKSA HEALEQCAKN S......... ....WERWYV A.v.I5 AIYEEDFQGF SYGFRPGRSQ HDALDALTVA L......... ..KSQKVNWI B.j.I2 AIYEGDFCGF SYGFRPGRGP HDALDALCTA I......... ..ETRQVNWI P.l.I1 QIYETDFLGF SYGFRPGRGQ HDALDALNVA V......... ..MERKVNWV Sr.me.I4 AVYEADFCGF SYGFRPGRNP HMALDALHTA I......... ..MSQRVNWM S.ma.I1 AVYENDFMGF SYGFRPGRSQ HDALDALATG L......... ..VRTNVNWV N.sp.I1 PAAEAMFNAR SYGFRPGRSC HDVQKLLFSN L.......NG GQANGLSKRI N.sp.I2 PAHEATFHAR SYGFRTGRAA HDAQQFLFSN L........S SKAKRISKRV N.sp.I3 PAHEATFHEH SYGFRPGRST HDAQSQIANY L........A SSKGGINKRI Ma.sp.I2 PIFEADFQSG SYGYRPKRMA HQAVNRVAIA I......... ...AQGKTQV S.ag.I2 PIFEADFQEF SYGFRPKRSA NQAIREIYKY L......... ...NYGCEWV

Domain 3 |-------------------------------------------------| N.a.I2 VDVDVAGFFE NID.H.DILL KLLRKR.IDD ERFIDLIRDM LKAGVME... N.a.I1 IDVDVVGFFD NID.H.DVLV SLLEKR.IAD RRFVRLIRGL LKAGYVE... L.l.I1 VEGDIKGCFD NID.H.VTLI GLINLK.IKD MKMSQLIYKF LKAGYLE... B.t.I2 IEGDIKGFFD NIN.H.DVLI NILRER.IAD ERFLRLIRKF LNAGYVE... OYPI1 IKIDLKGYFD TIN.H.ETLM KTLRKF.IRK NKTLSTINKW LKAGFMK... D.h.I1 VEGDIEACFD SFD.H.HVLI ELLQRR.IDD ASFISLMWKF LKAGYME... D.h.I2 VEGDIKAYFD TID.H.HMLV NILRRR.IQD ENFISLIWKF LRAGYLE... Sr.me.I2 IEGDIKGCFD NINHH.HLLE .RMRKR.IGD RRVVRLVGLF LKAGVLT... E.c.I4 IEGDLSSYFD TVH.H.RLLM KAVRRR.ISD ARFMTLLWKT IKAGHID... S.f.I1 IEGDLSSYFD TVH.H.RLLM KAVRRR.ISD ARFMTLLWKT IKAGHID... C.sp.I1 LDADISKCFD KIN.H.EKLL TKINTF.... PTMRRQIKAW LKAGVLD... G.v.I1 LDADIAKCFD RID.Q.QALL KKMNTS.... SAIRRQIRAW LKAGVME... T.sp.I1 LDADISKCFD RIN.H.DALL RKVGRT.... PYRR.LIKQW LKSGVFD... N.sp.I4 LDADIAKCFD KID.H.NVLL SKLNTF.... PTISRQIRAW LKAGVIDFSE B.a.I1 FEGDFQGCFD NLN.H.EHIL SCIEGF.... PY.SNAINQW LNAGCID... B.c.I1 VEGDFQGCFD HLN.H.EWIL KQTSYF.... PG.RKLLKRW LKMGYME... E.c.I5 LEGDIRGCFD NIS.H.QWLI DNT....... STDRQILTKW LKAGYRE... A.v.I1 MEGDIKGCFD NIS.H.DWLI ANV....... PLDKAVLRKW LKAGYLE... B.t.I1 MEGDIQGCFD HIS.H.EWLL NNIPMD.... ...KVMLRKW LKCGFVF... B.me.I2 FEGDFLGCFD HLN.H.NWIM EQTSMF.... PGN.TLIKRW LNMGYIE... A.v.I3 LEGDIRGCFD NIS.H.DWLL TNV....... PMDKTILRKW LQAGYVE... B.f.I1 VDVDLEKFFD RVN.H.DILI DRLKRRIDD. AGVIRLVRTY LNSGIMD... B.f.I2 VDVDLEKFFD RVN.H.DILI DRLQKRIDD. AGVIRLVRAY LNSGIMR... Ma.sp.I1 LEGDIKGCFD NIN.H.QWLL DNI....... PTDKKMLNAW LKAGVVH... R.m.I1 LEADIRGCFD HIS.H.DWLE RNV....... PMDKAILRKW LKAGVVF... Tr.e.I8 LDVDIKQDFD NIT.H.EYIL KAIGE..... IPGRELIKQW LKAGYLE... P.p.I2 LEGDIRGCFD NFN.H.EWML KNI....... PMDKTILRRW LQAGFID... M.a.I1-1 VEGDIKACFD EIN.H.TWIL DNI....... PMDKRILKEF LKAGYVE... M.a.I1-2 VEGDIKACFD EIN.H.NWIL I......... PMNKRILKEF LKAGYIE... M.a.I1-3 VEGDIKACFD EIN.H.TWIL DNI....... PMDKRILKEF LKAGYVE... M.m.I1-1 VEGDIKACFD EIS.H.NWIL DNI....... PIDKRILKEF LKAGYIE... M.m.I1-2 VEGDIKACFD EIS.H.NWIL DNI....... PIDKRILKEF LKAGYIE... X.f.I1 LEADIKGCFD HIS.H.DWLL GNV....... PMDKRMLEMW LKCGFME... R.r.I1 LEGDIKSCFD EIS.H.DYIL EHM....... PMDKAILRKW LQAGYVE... P.p.I1 VELDLEKFFD RVN.H.DILM ACIERR.IED KGALRLIRRY LEAGVMS... Sr.me.I3 VDVDLEKFFD RVN.H.DILI DRLSKR.ISD RRVIRLIRAY LNSGIMD... S.p.I1 VDIDLEKFFD TVP.Q.DRLM SLVHNI.IED GDTESLIRKY LHSGVII... S.ag.I1 VDIDLEKFFD TVP.Q.DRLM SLVHNI.IQD GDTESLIRKY FHSGVVI... A.v.I2 VDVDLEKFFD RVN.H.DILI DRLRKR.IDD AGVIRLIRAY LSAGIMD... A.v.I4 VDVDLSRFFD RVN.H.DILI DRLRRQ.VND TGVIRLVRAY LNAGIMD... D.h.I3 VDMDLEKYFD TVN.Q.SKLI QILSER.IKD GRVISLIHKY LRAGIMV... N.e.I1 VDLDLARFFD NVN.H.DLLM SLLSRS.IAD KRLLALIGRY LRAGVLV... N.e.I2 VDLDLARFFD NVN.H.DLLM SLLSRS.IAD KRLLALIGRY LRAGVLV... G.s.I1 VDIDLAKFFD TVN.H.DLLM TMVGRR.VRD KRVLTLIGRY LRAGVEV... O.i.I1 IDMDLEKFFD KVN.H.DKLM GVLAKR.IKD KELLRLIRKY LQSGVMI... P.p.I3 VEIDLEKFFD RVN.H.DILM ACIERR.VKD KCVLRLIRRY LEAGIMS... B.h.I1 VDIDLEKFFD KVN.H.DRLM RKLSSR.IQD PRVLQLIRRY LQTGVME... B.t.I3 VDLDLERFFD TVS.H.SKLI EILSRT.IKD GRVISLIHKY LRSGVIN... A.g.I1 VDVDLSKFFD RVN.H.DLLM TRLGDK.VKD KRLLRLIKRY LRAGFID... S.ma.I2 VDIDLSKFFD EVD.H.DMLM NRVGRK.IKD KALMRLLGKY LRAGIAE... M.sp.I1 VDLDLEKFFD KVN.H.DRLM WLLGRR.ISD KRVLKLIGKF LRSGILI... C.a.I1 VDIDLAKYFD TVN.H.DKLM ALVARK.IKD KRVLKLIRLY LQSGVMI... P.a.I1 VELDLEKFFD RVN.H.DILM ACIERR.IKD KCVLRLIRRY LEAGIMS... P.a.I2 VELDLEKFFD RVD.H.DLLM DLLARQ.VED PRVRRLVRRY LEAGVMA... S.t.I1 VDVDLSKFFD RVN.H.DLLM TQLRSK.VQD KRLLALIGKY LRAGVMV... B.me.I1 VDVDIKGFFD NVN.H.AKLI KQLWSLGIRD KALLSIISRL LKAEIIG... C.d.I1 VDIDIKGFFD NVN.H.GKLV KQLWTMKIRD KTFISILSRM LKAEVKG... B.a.I2 VDVDIKGFFD EVN.H.VKLM RQLWTLGIRD KQLLVIIRKI LKAPVQM... En.fm.I1 IEFDIKGFFD NVN.HSSKLI KQIWAMGIRD KHLIFILKRI LKAPIKM... E.f.I3 VDLDIKGFFD NIS.H.TKLI RQIWALGIRD KKLLCIIKEM LKAPVVL... E.f.I4 VDIDIKGFFD NVN.H.RLLI KQLWNIGICD KRVLAILSKS LKSPIQ.... E.f.I1 VDIDIKGFFD EVN.H.TKLM RQIWTMGIRD KQLLVIIRKM LKAPIVM... E.f.I2 ILIFKDFSMQ GNHVKTNADK FRPFRNSRIK KLFLFLTGKC LKAPFGF... N.p.I1 IELDIKKCFD RI.SH.KAIM DRLIAPQALK LGIFR....C LKAG...... Th.e.I1 LDADISGCFD NI.SH.EWLL ANTPLDKG.. ..ILRK...W LKSGFVW... Tr.e.I2 LDADISKCFD RIN.H.DALL RKIGRTPYRR ..LIKQ...W LKSGVFD... Tr.e.I3 LNADIAKCFD NID.H.EKLL DKIGTFPKVR RQIKA....W LKSGVYD... Tr.e.I4 LNADISKCMS EVN.H.HALL GKIDKSPYRQ ..LVKQ...W LKSGVFDK.. Tr.e.I5 LDAHIEKCFD GIN.Y.RKLL NKLNTYPGMR RQVKA....W LKSGFIE... Tr.e.I6 FDLINHDALL GKI.K.KSSY RRLIKQCLKS RVLDNNQFYP PQQLLFTYPD Tr.e.I7 LKADISQCFK CFD.H.EQLL KKLDTYPTLR KQIRV....W LKDGLIN... Tr.e.I9 LDADISKCFD RIN.H.DALL RKIGRTPYRR LIKQ.....W LKSGVFD... Sr.me.I1 LEFDIKGLFD NLP.H.DLLL KAVRKD.VKC NWALLYIERW LTAPMEK... B.j.I1 VDLDNKSFFD TID.H.ELLM RAVYRH.TKA DWIRLYIERW LKAPVEM... R.e.I1 VEFDIKAAFD QID.H.GLLM KAVRTH.IRE DWILLCIERW RVAPFET... E.c.I1 LEFDIKGLFD NIP.H.DLLL RAVDKH.CAD KWVRLYIRRW LTAPVQM... E.c.I3 LEVDISAFFD HVR.H.DLVL KALEHH.GMP KWVILYCRRW MEAPMQS... E.c.I2 LEFDIKGLFD NIP.H.ELIM KAVDKH.NPA RWVKLYIQRW LTAPMVM... P.l.I2 VEIDIKGFFD NID.H.ALLL KAVRHH.TQE RWLVMYIERW LKAPVQMP.. M.a.I5-1 LEFDIKGLFD NIN.H.DLLM KQVSMH.TDK PWIILYIQRW LKAPFQMA.. M.a.I5-2 LEFDIKGLFD NIN.H.DLLM KQVSMH.TDK PWIILYIQRW LKAPFQMA.. M.a.I5-3 LEFDIKGLFD NIN.H.DLLM KQVSMH.TDK PWIILYIQRW LKAPFQMA.. UMB VDLDIKGFFD NID.H.EKMM GILRKH.TNK KHILLYCDRW LKTPMQDR.. A.v.I5 LDADITSFFD EID.H.EWML MFLGHR.IAD RRMLGLICKW LQAGVME... B.j.I2 IDADIQNFFG AVS.Q.PWLV RFLEHR.IGD KRIIRLIQKW LKAGILE... P.l.I1 LDLDISRFFD TVE.H.DWLI RFIQHRIRDG RMVRLIRQ.W VTVGIVD... Sr.me.I4 LDADIRSFFD SVD.H.EWLL QMVAHR.IAD PRILQLIKLW LRAGILE... S.ma.I1 LDADISQFFD RVS.H.EWLI RFTEHR.IGD RRVIRLIRKW LTAGTSE... N.sp.I1 LELDIERCFD KID.H.KFLM QSVQLPKAAK QGI....FWA IKAGVR.... N.sp.I2 IELDIEKCFD RIN.H.STIM ENLIAPKGIK LGI....YRC LKAGIN.... N.sp.I3 LELDIEKCFD RIN.H.STIM SNLIAPQGLK QGI....FRA LKAGIN.... Ma.sp.I2 IDADLKSYFD TVQ.H.DLAL RKVSER.VDD DQVM...... .......... S.ag.I2 IDADLKGYFD TIP.H.DKLL LLVKER.VTD KSIIKLLSLW LEA.......

Domain 4 |-------------------------||------------ N.a.I2 ....GRAHTQ TYSGTPQGGI VSPILANIYL H.ELDEFMAG RITAFEKGKT N.a.I1 ....DWVFHK TYSGTPQGGV VSPMLANIYL H.ELDMFMQA KMAGFDKGKQ L.l.I1 ....NWQYHK TYSGTPQGGI LSPLLANIYL H.ELDKFVLQ LKM....... B.t.I2 ....DWVFHR TYSGTPQGGI ISPILANIYL D.KFDKYIKE YIN.....RF OYPI1 ....DGIKYE SLSGSPQGGI ISPLLANVYL H.YIDIKMDE LIK....... D.h.I1 ....QWEYNM TYDGVPQGSG ISPILSNIYL S.ELDTFMSE YKAAFDIRKT D.h.I2 ....DWQYNA TYSGSPQGSG ASPLLANLYL H.ELDLYMEE YKQ..RFDKG Sr.me.I2 ....EDQFLR TDAGTPQGGI ISPLLANIAL SAIEERYERW TYH....... E.c.I4 ....VGLFRA ASEGVPQGGV ISPLLSNIML N.EFDQYLHE RYL....... S.f.I1 ....VGLFRA ASEGVPQGGV ISPLLSNIML N.EFDQYLHE RYL....... C.sp.I1 ....NGHFSE TTEGTPQGGV ISPLLANIAL H.GLEKLVKE FAA....... G.v.I1 ....GSELFP TPTGTPQGGV ISPLLANIAL H.GMEERVKQ VSK....... T.sp.I1 ....NKHFSE TMEGTPQGGV ISPLLANIAL H.GKEKCLEK YAE....... N.sp.I4 YALREKSDHT TSMGVPQGGT ISPLLANIAL H.GMENRIKQ VAL....... B.a.I1 ....NKTFYK TETGTPQGGI ISPLLANIAL H.GMEKELGV RYH....... B.c.I1 ....QSFFAE TQEGTPQGGI ISPLLANIAL H.GMEETLGI TYK....... E.c.I5 ....KGQLFP VNSGTPQGGI ISPVLANIAL D.GLEALLAS EFK....... A.v.I1 ....SGQLNP TGAGTPQGGI ISPVLANLAL D.GLEKALES RFG....... B.t.I1 ....NKELFP TEEGTPQGGI ISPTLANMTL D.GLQTMLAE KYH....... B.me.I2 ....QDMLHT TTEGTPQGGI VSPLLANIAL C.GMEEEIGI VYK....... A.v.I3 ....QGTLFA TEAGTPQGGI ISPILANWTL D.GLEQAALT SVA....... B.f.I1 ....DGVVQQ RDQGTPQGGP LSPLLANVLL D.EVDKELER RGH....... B.f.I2 ....DGVVQE RGQGTPQGGP LSPLLANVLL D.EVDKALER RGH....... Ma.sp.I1 ....KGAFHA TEAGTPQGGI ISPVLANMAL D.GLEDALQA RFG....... R.m.I1 ....QGQFQA TEAGTPQGGI ISPTLANVAL N.GLEQQLAR FLE....... Tr.e.I8 ....AEVFHK TEGGTSSRGI ISPLLANIAF D.GMERLLAR YKT....... P.p.I2 ....EGTLFA TQAGTPQGGI ISPVIANMAL D.GLEAAVHA SVG....... M.a.I1-1 ....NYHLFP TEKGTPQGSP ISPIIGNMAL N.GLENALAM RFY....... M.a.I1-2 ....NYHLFP TEKGTPQGGP ISPIIGNMVL N.GLENALSM RFY....... M.a.I1-3 ....NYHLFP TEKGTPQGSP ISPIIGNMAL N.GLENALAM RFY....... M.m.I1-1 ....NYHLFP TEKGTPQGGP ISPIIGNMSL N.GLENALAM RFY....... M.m.I1-2 ....NYHLFP TEKGTPQGGP ISPIIGNMSL N.GLENALAM RFY....... X.f.I1 ....AGAWSE TEAGTPQGGI ISPTLANMAL D.GLEQLLEQ SFR....... R.r.I1 ....EGTLFE TRAGTPQGGV ISPTIANRVL D.GLEAAVDA SVG....... P.p.I1 ....GGIVSQ RQEGTPQGGP LSPLLSNILL D.EFDRKLKR RG........ Sr.me.I3 ....HGVVQE RVMGTPQGGP LSPLLANVLL D.EVDKELER RG........ S.p.I1 ....NGQRYK TLVGTPQGGN LSPLLSNIML N.ELDKELEK RG........ S.ag.I1 ....NGQRHK TLVGTPQGGN LSPLLSNIML N.ELDKGLEK RG........ A.v.I2 ....GGVVIE RDQGTPQGGP LSPLLANVLL D.EVDRALER RG........ A.v.I4 ....GGVVVE RLEGTPQGGP LSPLLANVLL D.AVDKELER RG........ D.h.I3 ....EGMFEE SPEGVPQGGP LSPLLGNIML N.ECDHELEK RG........ N.e.I1 ....GEHPQP SEVGTPQGGP LSPLLANVLL H.QFDLELER RG........ N.e.I2 ....GEHPQP SEVGTPQGGP LSPLLANVLL H.QFDLELER RG........ G.s.I1 ....DGRLEK TRMGVPQGGP LSPLLANILL D.HLDKELES RG........ O.i.I1 ....NGIVVS SEEGTPQGGP LSPLLSNIIL D.DLDKELEE RG........ P.p.I3 ....GGVVSP RQEGTPQGGP LSPLLSNILL D.ELDRELER RG........ B.h.I1 ....RGLVSP NTEGTPQGGP LSPLLSNIVL D.ELDNELEK RG........ B.t.I3 ....RGMFEM STEGTPQGGP LSPLLSNIML N.ELDKELER RG........ A.g.I1 ....NQFKGE SRVGVPQGGP LSPLLANIML D.SLDKELEK RG........ S.ma.I2 ..RETGLWFE STKGVPQGGP LSPLLSNILL D.ELDKKLTY KH........ M.sp.I1 ....GGLENQ RISGTPQGSP LSPLLSNIVL D.ELDKELER RG........ C.a.I1 ....NGVVSE TERGCPQGGP LSPLLSNIML T.ELDRELEK RG........ P.a.I1 ....GGVVSP RQEGTPQGGP LSPLLSNILL D.ELDRELER RG........ P.a.I2 ....GGLVSL RREGTPQGGP LSPLLSNILL N.ELDRELSR RG........ S.t.I1 ....NGQFEA SFEGVPQGGP LSPLLSNIML D.SLDKELES RG........ B.me.I1 .......EGF PKKGTPQGGI LSPLLSNIVL N.ELDWWVSN QWE....... C.d.I1 .......IGK STKGTPQGGI LSPLLANVVL N.ELDWWIDS QWD....... B.a.I2 ...PDGTTMF PTKGTPQGGI LSPILANVNL N.EFDWWISR QWE....... En.fm.I1 ...TNGTITY PEKGTPQGGI ISPLLANIVL N.ELDHWVES QWQ....... E.f.I3 ...PNGEKTY PARGTPQGGI LSPLLANIVL N.ELDWWIAS QWE....... E.f.I4 .....GE.GI SSKGTIQGGI ISPLLSNVVL N.DLDHWVSK QWH....... E.f.I1 ...RNGNVVF PTKGTPQGGI LSPLLANICL N.EFDWWIAN QWE....... E.f.I2 .TRTALFLKF PTKGTPQGGI LSPLLSNICL N.EFDWWIAR QWE....... N.p.I1 .....ISLKF PEQGTPQGGV VSPLLANIAL N.GIEDVNKS YRR....... Th.e.I1 ....KQQLFP THAGTPQGGV ISPVLANITL D.GMEELLAK HLR....... Tr.e.I2 ....NKQFSD TLEGTPQGGV ISTLLVNIAL H.GMEKCLEK YAE....... Tr.e.I3 ....NESWFL MDEGISQGEV ISGLWANIAL H.GMEKIVKE FAY....... Tr.e.I4 ...SQFDPPL LELGTPQGEV ISPLLANIAL H.GMEKCLQD FAE....... Tr.e.I5 ....EDVFYS NESRTPQSGL IYPLLVNITL H.GMQEALHE EFY....... Tr.e.I6 SFLLGNRCGL VELDTAQGEV MSPLLANITL H.GIEKRLME FAK....... Tr.e.I7 .......... GKDLFKWEEV ISPLLANIAF H.DTEEKIKH YTK....... Tr.e.I9 ....NKQFSN TVEGTPQGGV ISPLKSKHRP T.GKEKCLKN YAE....... Sr.me.I1 ....NGEVIE RSRGTPQGGV VSPILANLFL HYAFDLWMTR THP....... B.j.I1 ...PDGSVRA RTTGRSQGGV VSPILANLFL HYVFDVWMKG SYP....... R.e.I1 ...ADGVRVP RTRGTPQGGV SSPILMNLFT HYTFDRWMQR TSP....... E.c.I1 ...PDGTLKE RNKGTPQGGV ISPVLANLFL HYVFDKWLSL HYP....... E.c.I3 ..CENGELIT RTRGTPQGGV ISPLLANLFL HYAFDLWMER EYR....... E.c.I2 ...SDGEVRA RTMGTPQGGV ISPLLANLFM HYVFDKWLAK YYP....... P.l.I2 ....DGRVQV RNRGTPQGGV ISPLISNLFL HYAFDMWMKR QFP....... M.a.I5-1 ....DGTVNE RTKGTPQGGV VSPLLANLFL HYAFDQWMDS HHR....... M.a.I5-2 ....DGTVNE RTKGTPQGGV VSPLLANLFL HYAFDQWMDS HHR....... M.a.I5-3 ....DGTVNE RTKGTPQGGV VSPLLANLFL HYAFDQWMDS HHR....... UMB ....VGGVQA RMKGTPQGGV ISPLLANLYL HEAFDQWIST TQP....... A.v.I5 ....DGRRLA ATKGTPQGAV ISPLLANIYL HYVLDLWARQ WRQ....... B.j.I2 ....DGVVTA DDRGTGQGPV ISPLLGNIYL HYALDLWAKR WRQ....... P.l.I1 ...EHGHRQK SHCGTPQGAV ISPLLANIYL HYSFDLWLNA WRK....... Sr.me.I4 ....SGETYE TDRGTPQGAG ISPLLANIFL HYILDLWVHQ WRR....... S.ma.I1 ....EGQWRA TEEGTPQGAV ISPLLANIYL HYVFDLWAHQ WRR....... N.sp.I1 .....GEFPS SESGTPQGGV ISPLLANIVL HGLENVGHEL RYK....... N.sp.I2 .....PEFP. .EQGTPQGGV VSPLLANIAL NGIESIHRYH KDN....... N.sp.I3 .....PEFP. .EQGTPQGGV VSPLLANIAL NGIDLHQYHD CNY....... Ma.sp.I2 HLLKLIFKTS GKRGVPQGGV ISPLISNLYL NEVDKMLERA KEV....... S.ag.I2 GIMEDNQVRS NILGTPQGGV ISPLLANIYL NALDRYWKNN RLE.......

4/5 spacer ------------------------------------------------------ N.a.I2 RATNPEYRRL AGRIAKRRER LKRLEASDNA DQVTVKAILA EINTLSKQMR N.a.I1 RSPSPDARRI RNRLSYVRRT VDQLRAKGRG DDPRVTSFLE EIGRLKAERL L.l.I1 ..KFDRESPE RITPEYRELH NEIKRISHRL KKLEGEEKAK VLLEYQEKRK B.t.I2 NKGVTRKGDA RYKLYEQRRY RLAKKLKNEK DVKVRKQMTA EIKRLREERN OYPI1 .......... .......... .......EGT PIRKANPEYG KAYHQGMHHK D.h.I1 HGRKPSSNYC HARYMASKYR KESRAIWGNL TPSEKKSRMK EQRALSVKQR D.h.I2 NRRQAGKDYG RAQRTHQYRK VKYDRLWLTL TDEEKKAAQR EIRALRKRML Sr.me.I2 .......... .......... .......... ....RKKTQA RRKSNGVAAA E.c.I4 .......... .......... .......... ..SGKARKDR WYWNNSIQRG S.f.I1 .......... .......... .......... ..SGKARKDR WYWNNSIQRG C.sp.I1 .......... .......... .......... .......... .......... G.v.I1 .......... .......... .......... .......... .......... T.sp.I1 .......... .......... .......... .......... .......... N.sp.I4 .......... .......... .......... .......... .......... B.a.I1 .......... .......... .......... .......... .......... B.c.I1 .......... .......... .......... .......... ........KN E.c.I5 .......... .......... .......... .......... .......... A.v.I1 .......... .......... .......... .......... .......... B.t.I1 .......... .......... .......... .......... .......... B.me.I2 .......... .......... .......... .......... ........KT A.v.I3 .......... .......... .......... .......... .......... B.f.I1 .......... .......... .......... .......... .......... B.f.I2 .......... .......... .......... .......... .......... Ma.sp.I1 .......... .......... .......... .......... .......... R.m.I1 .......... .......... .......... .......... .......... Tr.e.I8 .......... .......... .......... .......... .VKTYQCTRP P.p.I2 .......... .......... .......... .......... .......... M.a.I1-1 .......... .......... .......... .......... ........SR M.a.I1-2 .......... .......... .......... .......... ........SR M.a.I1-3 .......... .......... .......... .......... ........SR M.m.I1-1 .......... .......... .......... .......... ........SR M.m.I1-2 .......... .......... .......... .......... ........SR X.f.I1 .......... .......... .......... .......... .......... R.r.I1 .......... .......... .......... .......... .......... P.p.I1 .......... .......... .......... .......... .......... Sr.me.I3 .......... .......... .......... .......... .......... S.p.I1 .......... .......... .......... .......... .......... S.ag.I1 .......... .......... .......... .......... .......... A.v.I2 .......... .......... .......... .......... .......... A.v.I4 .......... .......... .......... .......... .......... D.h.I3 .......... .......... .......... .......... .......... N.e.I1 .......... .......... .......... .......... .......... N.e.I2 .......... .......... .......... .......... .......... G.s.I1 .......... .......... .......... .......... .......... O.i.I1 .......... .......... .......... .......... .......... P.p.I3 .......... .......... .......... .......... .......... B.h.I1 .......... .......... .......... .......... .......... B.t.I3 .......... .......... .......... .......... .......... A.g.I1 .......... .......... .......... .......... .......... S.ma.I2 .......... .......... .......... .......... .......... M.sp.I1 .......... .......... .......... .......... .......... C.a.I1 .......... .......... .......... .......... .......... P.a.I1 .......... .......... .......... .......... .......... P.a.I2 .......... .......... .......... .......... .......... S.t.I1 .......... .......... .......... .......... .......... B.me.I1 .......... .......... .......... .........S FETHKLYKSN C.d.I1 .......... .......... .......... ........GF PTKRKYSSLL B.a.I2 .......... .......... .......... .TFKAKKVKP RCMRGIWCND En.fm.I1 .......... .......... .......... ENPVTKNYVV HINKSGSPCK E.f.I3 .......... .......... .......... EMPTKTKFKT RSNAQGTEIK E.f.I4 .......... .......... .......... .........T FETKYPYTKG E.f.I1 .......... .......... .......... ERTVKELKHH YRKNGAWDKG E.f.I2 .......... .......... .......... ERECSELVPQ FNSKGTRHKS N.p.I1 .......... .......... .......... .......... .......... Th.e.I1 .......... .......... .......... .......... .......... Tr.e.I2 .......... .......... .......... .......... .......... Tr.e.I3 .......... .......... .......... .......... .......... Tr.e.I4 .......... .......... .......... .......... .......... Tr.e.I5 .......... .......... .......... .......... ..RKYTTKAI Tr.e.I6 .......... .......... .......... .......... ....TLDLKN Tr.e.I7 .......... .......... .......... .......... .......... Tr.e.I9 .......... .......... .......... .......... .......... Sr.me.I1 .......... .......... .......... .......... .......... B.j.I1 .......... .......... .......... .......... .......... R.e.I1 .......... .......... .......... .......... .......... E.c.I1 .......... .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 .......... .......... .......... .......... .......... P.l.I2 .......... .......... .......... .......... .......... M.a.I5-1 .......... .......... .......... .......... .......... M.a.I5-2 .......... .......... .......... .......... .......... M.a.I5-3 .......... .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 .......... .......... .......... .......... .......... P.l.I1 .......... .......... .......... .......... .......... Sr.me.I4 .......... .......... .......... .......... .......... S.ma.I1 .......... .......... .......... .......... .......... N.sp.I1 .......... .......... .......... .......... .......... N.sp.I2 .......... .......... .......... .......... .......... N.sp.I3 .......... .......... .......... .......... .......... Ma.sp.I2 .......... .......... .......... .......... .......... S.ag.I2 .......... .......... .......... .......... ..........

Domain 5 ----------------||-------------| N.a.I2 SLPSRDAMDA GFRRLRYCRY ADDFLIGVIG SKDDARGV.F AEVRTFLTEV N.a.I1 AVPASDAFDP NYRRLRYCRY ADDFIIGVTG SKSEARQI.M EEVRTYLSDH L.l.I1 RLPTLPCTSQ TNKVLKYVRY ADDFIISVKG SKEDCQWI.K EQLKLFIHNK B.t.I2 NYPARNEMDS SIKRLKYVRY ADDFLIGITG NLEDCKTV.K EDIKNYLNEA OYPI1 LGIDRQINLN PKTRVEYIRY ADDFIIGIKG KYDKAETI.K NQVTQWLEQD D.h.I1 ETPAHDVFDD TFKIIQYARY ADGFIVGVIG SKTDAERV.K TDIKQFLAGE D.h.I2 ECPANDPMDG TYRRIQYVRY CDDFLVGIIG SKTDAEKV.K ADICRFLSDK Sr.me.I2 ASARDSDRIA GRCVYLPVRY ADDFVVLVSG SLEEAMAE.K SALADYLIKT E.c.I4 RSTAVRENWQ WKPAVAYCRY ADDFVLIVKG TKAQVEAI.R EECRGVLEGS S.f.I1 RSTAVRENWQ WKPAVAYCRY ADDFVLIVKG TKAQAEAI.R EECRGVLEGS C.sp.I1 ..SQRGGKVK NQNSISLIRY ADDFVILAP. NKTQIIVL.K EIVKTWLAE. G.v.I1 .......... ...MAQLIRY ADDFVCIHT. DQQIVQSC.Q TVLEEWLAG. T.sp.I1 ..TLPGVKAK NKQALTLVRY ADDFVILHK. DIKVLLQA.K AVIQDWLNQ. N.sp.I4 ..TLPGCKSE NRQAISLIRF ADDFVILHK. DLAVIQRC.Q QIISEWLSE. B.a.I1 .FPKRDGAML YPDSIGIVRY ADDFVIVCN. SKEEAESM.Y AKLQPYLDK. B.c.I1 YKANDSYIMN PACKFTLIRY ADDFVVLTE. TKEQALSV.Y MRLRPYLKD. E.c.I5 ..KRTVKGRL VNPKVNYVRY ADDFIITGE. SKELLESQVL PVVRRFMAE. A.v.I1 ...QRNTKAS YKTKVNYVRY ADDFVITGI. SKELLVNEVK PVVAAFMAE. B.t.I1 KKFVTRKTTT YYPKVHLVRY ADDFIITGR. NKEALEEI.K PLVVDFLKE. B.me.I2 YKSNGGYKID PKCKIGRVLY ADDFVIVTE. TKEQAESM.Y QNLTPYLRK. A.v.I3 ....STERRR RPFKVHAVRY ADDFIVTGA. SKSLLEHQVR PAIEAFLKE. B.f.I1 .......... .....CFARY ADDANVYVR. SRRAGERVMA LLRRLYGRL. B.f.I2 .......... .....CFVRY ADDCNVYVR. SRRAGARVMA LLRRLYGKL. Ma.sp.I1 ...SKISPRR KACRINLVRY ADDFIITGS. SPELLENEVK PLVQNFLSE. R.m.I1 ..TTLGVNQT RKLKVNVVRY ADDFVITGS. TPEVLEHEVK PWVEQFLAI. Tr.e.I8 TTDEEYTKKK KLDKYGFIRY ADDFIITARS EEDIKAIIPT IEK.WLSE.R P.p.I2 ....PTKRAR ERSKINVVRY ADDFVVTGI. SKEILEHSVL PAVRQFMAI. M.a.I1-1 SDGTIDKSHQ NRHKVNCARF ADDFVATAD. SPETALEIID ..VIQEFLDP M.a.I1-2 SDGTIDKSHQ NKHKVNYVRY ADDIV.TAN. SEETAKEIKD ..IIATFLKE M.a.I1-3 SDGTIDKSHQ NRHKVNCARF ADDIV.TAD. SEETAQEIKD ..LLKTFLKE M.m.I1-1 SDGTIDKSHQ NRRKVNYVRF ADDLVVTAD. SPETALEIID ..VIQAFLDP M.m.I1-2 SDGTIDKSHQ NRRKVNYVRF ADDLVVTAD. SPETALEIID ..VIQAFLDP X.f.I1 ..SRMRDRQI TNPKVNLVRY ADDFVITGD. SEKLLIKEVK PLVERFLAD. R.r.I1 ....SSKSTY RKAKPHVIRY ADDFIVTSA. SKEVLEHKVL PAIRKYLAV. P.p.I1 .......... ....HRFVRY ADDANIMSA. LLGLVNRC.L ANVERFLCQR Sr.me.I3 .......... ....HCFVRY ADDCNVYVG. SRKAGERVMA LLRRLYGRLH S.p.I1 .......... ....LRFVRY ADDCVITVG. SEAAAKRV.M YSVSRFIEKR S.ag.I1 .......... ....LRFVRY ADDCVITVG. SEAAAKRV.M HSVSSYIEKR A.v.I2 .......... ....HCFVRY ADDCNVYVR. SRRAGERV.M NLLRKLYG.R A.v.I4 .......... ....HRFARY ADDCNVYVR. SQKAGERV.M ALLKRCYD.K D.h.I3 .......... ....HRFVRY ADDLMIFCR. SRKAAQRT.M EHIVPYIEKK N.e.I1 .......... ....HRFARY ADDVIILVK. SRRAAERV.M QSLTYFLQST N.e.I2 .......... ....HRFARY ADDVIILVK. SRRAAERV.M QSLTYFLQST G.s.I1 .......... ....HKFVRY ADDFVILVK. SERAGERV.M GSVRKYLTNK O.i.I1 .......... ....LRFVRY ADDCNIYVR. TKKAGNRV.M NSITTFIEEK P.p.I3 .......... ....HRFVRY ADDANIYVR. SPRAGERV.L VSVERFLRER B.h.I1 .......... ....LKFVRY ADDCNIYVR. SKRAGLRI.M ESVTSFIENR B.t.I3 .......... ....HPFVRY ADDAMIFCK. SKRAAKRV.R ESITLFIEGK A.g.I1 .......... ....HKFARY ADDFTILVK. SQRAGERV.L RSISQYLQSR S.ma.I2 .......... ....LKFARY ADDIIILVK. TKSEGLII.Q REITAFITKR M.sp.I1 .......... ....HRFVRY ADDMILLVR. SQEAAERA.Y SSITSFIENR C.a.I1 .......... ....HKFCRY ADDNNVYVR. SKKAGDRV.M RSITRFIENK P.a.I1 .......... ....HRFVRY ADDANIYVR. SPRAGERV.L VSVERFLRER P.a.I2 .......... ....HRFVRY ADDANVYVR. SRQAGERV.L ASLERFLEQR S.t.I1 .......... ....HKFARY ADDFIILVK. SIRAGERV.L KSITQYLATK B.me.I1 LGRYNALKQS NLKHCYIVRY ADDFKILCR. TRSQAIKM.Y YAVNDFLHTR C.d.I1 SKTQSIRKYS NLKEIKIVRY ADDFKIMCK. DYHTAQKI.F LATKQWLKVR B.a.I2 VVTTQLTKTS KMKPMYIVRY ADDFKIFTN. TRSNAEKI.F KATQMWLEER En.fm.I1 SNAYKEMKKT KLKEMYMVRY ADDFRVFCR. YKESAEKA.K IAITQWIEQR E.f.I3 SHAYRALRRS RLKEMHAVRY ADDFKIFCA. THEDAVRA.Y KATELWLKDR E.f.I4 YNKFRALRDT NLKQGYIVRY ADDFKIMTN. DYPSALKW.F HAVKLYLKDR E.f.I1 NIYSKLRSHT SLKEMYLVRY ADDFKIFCR. TGEEAQRA.F YATQKWLRER E.f.I2 HDYRKLRSST TLKQVYIVRY ADDFKLFCKI DRRLKDSSGA TKMWLKERL. N.p.I1 .......... ....GYAVRY ADDMIIFLQ. PQDDASKFIK NIEEFLAER. Th.e.I1 .......... .GQKVNLIRY ADDFVVTGK. DEETLEKARN LIQEFLKER. Tr.e.I2 ..TLPGKKRD NKQALSLIRY ADDFVILHE. DIKVVMQAKT VIQEWLNQV. Tr.e.I3 ..SLSGKKVK NEKEITLVRY ADHFVILHP. NLNVVTKAKA LVEEFLRGM. Tr.e.I4 ..TLPGNKRD NIQALSLVRY AGNFVILHK. DIEVVMQAKA VVQEWLNNI. Tr.e.I5 APKYSIRPGT LFHPPLFHRY AFDLVLLHK. SRKVIEESQV IINDWLRSM. Tr.e.I6 KKGAQMSWQS KCQSLILVDY VDEFVILQE. DIKVLLQAKT VMQEWLNQV. Tr.e.I7 ......ALSD QCEGLSLIRY GGNLVIAHK. NIEVVQKCQY IIRECLSDL. Tr.e.I9 ..TLRGNKRN NKHALSLIRY ADDFVILHK. DIKVLLQAKT VIQEWLNHV. Sr.me.I1 .......... ...DLPWCRY ADDGLVHCQ. SEQQAEAL.R VELSSRLAA. B.j.I1 .......... ...HIPFERY ADDIICHCR. TRQEAEEL.K SALERRFAD. R.e.I1 .......... ...NCPFARY ADDAVVHCN. SRRQAEYV.M RSIAARLAA. E.c.I1 .......... ...EIPWCRY ADDGLIHCG. SKQQAEEL.L NKLAKRFQE. E.c.I3 .......... ...GVPFERY ADDIVVHCS. RMSDATRL.K NRLSERFSE. E.c.I2 .......... ...KVPWYRY ADDGILHCH. SEAEATEM.R EVLRKRFSE. P.l.I2 .......... ...GVPFERY ADDVVCHCH. SQSQAEAL.I SKAGQRFAQ. M.a.I5-1 .......... ...YNPFERY ADDSVIHCR. SKKDADRL.R IKLEKRLSE. M.a.I5-2 .......... ...YNPFERY ADDSVIHCR. SKKDADRL.R IKLEKRLSE. M.a.I5-3 .......... ...YNPFERY ADDSVIHCR. SREEAERL.W IELDKRLSE. UMB .......... ...RIVFERY ADDIVIHTR. SMEQSHFI.L DKLKARLKS. A.v.I5 ........RH ARGEMIVVRY ADDSVVGFR. TQWQAQRF.L VQLQERMAR. B.j.I2 ........RE VSGGMIIVRY ADDVVVGFE. REDDARRF.L DAMRARLEE. P.l.I1 .........R VQGEVVMIRY ADDAVLGFQ. KHQDARAC.Q SLLQRRLMQ. Sr.me.I4 ........RH ARGRIVIVRY ADDFVMGFE. KKDDAQEM.L LALKERLGE. S.ma.I1 ........RY ATGNVVMVRY ADDIVIGFD. KRYDARRF.R IAMQRRLRE. N.sp.I1 ....VRSGGR QIDTIKGFRY ADDVVFLLK. PEDNPEALRQ NIDTFLEA.. N.sp.I2 .QRITNKTPE SDIRYPSVRY ADDMVIVLR. PQDDANEILA KIEDFLNA.. N.sp.I3 .KKITPSTPE RNIKKACVRY ADDMVFFLR. PEDDAEEILE KISQFLAQ.. Ma.sp.I2 ......TRKG KYTHIEYARF ADDLVILVDG HHRWNGLARK VYQRLGEELA S.ag.I2 .........G RGHDAHLIRY ADDFVIL... ...CSNNPKK YYQYAKQRID

Domain 6 Domain 7 |-------------| |-------| N.a.I2 LALTVSEE.K SGIRK..... .......... .ASDGTKFLG YEVRTYTGRQ N.a.I1 LKLAVSAE.K SGIHK..... .......... .ASDGARFLG YEVR.TMTNP L.l.I1 LKMELSEE.K TLITH..... .......... .SSQPARFLG YDIR....VR B.t.I2 LKLELSDE.K TLITN..... .......... .AQKPAKFLG YDVF....IR OYPI1 LKLTISKD.K SKIVK..... .......... .ANKGTRFLS YMYM...... D.h.I1 LKLKMSDA.K TKITH..... .......... .SGDKARFLG YDIY....VS D.h.I2 LKLTLSPE.K TLITH..... .......... .GQDKARFLG YDIA....VC Sr.me.I2 TGLTLLPE.K TKVTA..... .......... .MTEGFEFLG FRFS...... E.c.I4 LKLRLNMD.K TKIPH..... .......... .VNDGFIFLG HRLI...... S.f.I1 LKLRLNMD.K TKITH..... .......... .VNDGFIFLG HRLI...... C.sp.I1 MGLELNPN.K TRIVS..... TFKSSEIFA. SQEVGFNFLG FNVK...... G.v.I1 MGLELKPS.K TRIAHT.... .....LLLE. EGQPGFDFLG FTVR...... T.sp.I1 VGLELKPE.K TKIAH..... ...TLEEYE. GNKPGFDFLG FTVR...... N.sp.I4 LGLELKPS.K TRISH..... ....TLNMY. EGKVGFDFLG FTVR...... B.a.I1 RGLKLAEE.K TRVVH..... .......... .ITDGFDFLG FNFR...... B.c.I1 RGLELSPE.K TKVTH..... .......... .IEEGFEFLG FLIR...... E.c.I5 RGLMLSPE.K TKITH..... .......... .IEEGFDFLG QNIR...... A.v.I1 RGLSLAAE.K SLFTH..... .......... .VSEGFDFLG QNVR...... B.t.I1 RGLTLSEE.K TKITH..... .......... .IDDGFDFLG YNIR...... B.me.I2 RGITLSKE.K TRVTH..... .......... .IEDGFDFLG FSLR...... A.v.I3 RGLELSAK.K THITH..... .......... .ISEGFDFLG QNVR...... B.f.I1 R.LKVNET.K SAVAS..... .......... ..VFGRKFLG YSLW...... B.f.I2 C.LKVNEA.K SAVAS..... .......... ..VFGRKFLG YSLW...... Ma.sp.I1 R.LALSAE.K TSITY..... .......... .ITDGFDFLG QNIR...... R.m.I1 RGLSLSTE.K TRIVS..... .......... .IDEGFDFLG WNFR...... Tr.e.I8 GLELNKD.KT NLVH...... .......... IEQGFNFLGF NVR....... P.p.I2 RGLELSEE.K TKITH..... .......... .IAEGFDFLG QNVR...... M.a.I1-1 RGLKLSEE.K TLVTN..... .......... .ISEGFNFLG WNFR...... M.a.I1-2 RGLELSDD.K TLITN..... .......... .IDAGFDFLG WNFR...... M.a.I1-3 RGLELSDD.K TLITN..... .......... .ITEGFDFLG WNFR...... M.m.I1-1 RGLKLSEE.K TLVTN..... .......... .ISEGFNFLG WNFR...... M.m.I1-2 RGLKLSEE.K TLVTN..... .......... .ISEGFNFLG WNFR...... X.f.I1 RGLTLSAE.K TRVTH..... .......... .IDEGFDFLG QNVR...... R.r.I1 RGLELSDE.K SRITN..... .......... .IADGFDFLG QNVR...... P.p.I1 LKLTVNRK.K SQVAE..... .......... ..AWKCDYLG YGMS...... Sr.me.I3 LTI..N.EGK SAVTS..... .......... ..VFGRKFLG FSFW...... S.p.I1 LGLKVNMT.K TKITR..... .......... ..PRELKYLG FGFW...... S.ag.I1 LGLKVNMT.K TKIVR..... .......... ..PNKLKYLG FGFW...... A.v.I2 LKLRVNEA.K SAVAS..... .......... ..AFGRKFLG YAFW...... A.v.I4 LRLKINES.K SAVAG..... .......... ..VFGRSFLG YCLW...... D.h.I3 LFLKVNRE.K SKVTH..... .......... ..VNYVKYLG YSFY...... N.e.I1 LKLTVNLA.K SQVAP..... .......... ..MSECSFLG FTLV...... N.e.I2 LKLTVNLA.K SQVAP..... .......... ..MSECSFLG FTLV...... G.s.I1 LKLTVNED.K SKVAR..... .......... ..SGDLSFLG FVFK...... O.i.I1 LRLKVNKE.K SAVDR..... .......... ..PWKRKFLG FSFT...... P.p.I3 LKLTVNRK.K SQVAR..... .......... ..AWKCDYLG YGMS...... B.h.I1 LKLKVNRE.K SAVDR..... .......... ..PWNRKFLG FSFT...... B.t.I3 LFLKVNHE.K TVVSY..... .......... ..VKGVKFLG YSFY...... A.g.I1 LKLVVNTD.K SRVVK..... .......... ..TNESQFLG FTFK...... S.ma.I2 LKLKVNES.K SRVGP..... .......... ..VSGSKFLG FTFR...... M.sp.I1 LLLKVNKD.K SRICR..... .......... ..PYQLNFLG HSIM...... C.a.I1 LKLKVNKE.K SAVDR..... .......... ..PWRRKFLG FTFY...... P.a.I1 LKLTVNRK.K SQVAR..... .......... ..AWKCDYLG YGMS...... P.a.I2 LRLRLNRA.K SQVIR..... .......... ..PWRSSYLG YGMT...... S.t.I1 LKLAVNEQ.K SQVVK..... .......... ..VGQSKFLG FTFN...... B.me.I1 LRLEISEQ.K SKVVN..... .......... LKKNSSEFLG FRSK...... C.d.I1 LDLDISPE.K SKVTN..... .......... LRKNYSDFLG FKLK...... B.a.I2 LKLSISAE.K SKVTN..... .......... LTKQQSEFLG FTLK...... En.fm.I1 LKLEVSQE.K TRIVN..... .......... VRKRYSDFLG FKIK...... E.f.I3 LGLEISPD.K SKVVN..... .......... LKRQYSDFLG FKLK...... E.f.I4 LKLDISNE.K SKIVN..... .......... LRKRKSEFLG FTIC...... E.f.I1 LKLPISME.K SKVTN..... .......... LNKAESEFLG FSIR...... E.f.I2 .RLPISEE.K SKVTN..... .......... LKKKSSEFLG ITLK...... N.p.I1 .GMEISPE.K TKVTP..... .......... .ATDGFDFLG WNFK...... Th.e.I1 .GLTLSPE.K TKIVH..... .......... .IEEGFDFLG WNIR...... Tr.e.I2 .GLELKPE.K TKIAH..... ...TLEEYE. GNKPEFDFLG FNIR...... Tr.e.I3 .GLELKPE.K TRLTH..... ...TLIQVG. EEEPGFNFLG FNIR...... Tr.e.I4 .GLELKPE.K TRIAH..... ...TLEEYE. GNQPGFDFLG FTVR...... Tr.e.I5 .GLQLKDS.K TKLAH..... ....TLGDG. KVQTGFDYLG FNVR...... Tr.e.I6 .RLELKQE.L TRIAN..... ...ALEEYK. GNKPGLDFFG FTMR...... Tr.e.I7 .CLELKPS.Q IIIYH..... ...TLYRCG. EEEPGFDFLG FNIR...... Tr.e.I9 .GLELKPE.K TKIAH..... ...TLEEYD. GNKPGFDFLG FTIR...... Sr.me.I1 CGLQMHPT.K TKIVY..... CKDQRRREA. YPNVTFDFLG YQFR...... B.j.I1 CHLLLHPE.K TKVVY..... CADSNRRRS. YPQIHFDFLG FSFR...... R.e.I1 CGLTMHPE.K SKIVY....C RDSRNRSER. HLHASFTFLG FTFR...... E.c.I1 CGLELHPE.K TKIVY....C KDSRQ.ANH. ET.VQFDFLG YTFR...... E.c.I3 VGLVLNAG.K TNIAY..... ..IDTFKRR. NVATSFTFLG YDFK...... E.c.I2 CGLEMHPE.K TRVIY..... CKDGSRKGD. YEHTMFDFLG YTFR...... P.l.I2 CGLELHPQ.K TRMVY..... CKDADRRGN. YAETRFDFLG YTFR...... M.a.I5-1 FGLELHPT.K TRIVY..... CKDDDRQED. YPETKFDFLG YTFR...... M.a.I5-2 FGLELHPT.K TRIVY..... CKDDDRQED. YPETKFDFLG YTFR...... M.a.I5-3 FGLELHPS.K TRIVY..... CKDDDRQGD. YPETKFDFLG YTFR...... UMB YSLELHPD.K TKIVY..CYR TARFHKEGK. EIPVSFDFLG FTFK...... A.v.I5 FGLSLNAS.K TRLIEFGRFA VQNRRRQGL. GKPETFDFLG FTHC...... B.j.I2 FELTLHPA.K TRLIEFGRHA AAQRKQRGL. GKPETFAFMG FTFI...... P.l.I1 FGLKVHPA.K TRLVRFGRFA LKQYEERPER GKPGTFDFLG FTHY...... Sr.me.I4 FGLALHEG.K TRLIEFGRFA ALSRQRRGE. RKPETFAFLG FIHY...... S.ma.I1 FGLTVHPE.K TRLMEFGRFA AENRAIRGK. GKPETFNFLG FTHI...... N.sp.I1 RGLKVKEA.K TKIVH..... .......... .STDSFDFLG WNFV...... N.sp.I2 RGMKVSAK.K TKITA..... .......... .TTDGFDFLG WHII...... N.sp.I3 RGLKISEK.K TKLTA..... .......... .STDGFDFLG WNFY...... Ma.sp.I2 KLKVQLNLEK TRVVD..... .........L TRGEDFTFLG FNIR...... S.ag.I2 KLGLTLNEEK TRIVH..... .......... .ATEGFDFLG YTLR......

7/X spacer Domain X |------------------||--------------------------------- N.a.I2 WTVRSQNGTQ HFKRRPPSEV MQLNVPWDRV TAFVARKAYG .......EWS N.a.I1 NPHKAIFDGR PAVRRGLADR MKLLVPRDRV VRFVNSKEWG .......DYD L.l.I1 RSGTIKRSGK VKKRTLNGSV ELLIPLQDKI RQFIFDKKIA ....IQKKDS B.t.I2 RCNDLRKDKY GKTVRAFGHK PVLYLNFETM RKKLFDYKAA .RIAVVNGKE OYPI1 .......VKV KPTSSKLTKK THKKSLNGRV QIQVPKAKAK EYGYEYNWLK D.h.I1 REQCAKRRKD GAIMRSQTGS IKLLVPHEKW VGKLREYKAF KTVLTSDGKE D.h.I2 QDNTTRRTSR GQSRVH.SGK VKLYVPKDKW VGKLREYGVL KVASDGNGKE Sr.me.I2 .........V HWDKRYGYGP RVEIPKAKAA NLRHKVKQLT .......... E.c.I4 .......... ..RKRSRYGE MRVVSTIPQE KARNFAASLT .......... S.f.I1 .......... ..RKRSRYGE MRVVSTIPQE KARNFAASLT .......... C.sp.I1 QYKVGKNDSG KLSNGKKLGY KTLIKPSVKS VKKHYDDIAR .......... G.v.I1 QFPVGKYHTG TNSRGKPLGF KTIIKPSKKS IKTHTEKLRR .......... T.sp.I1 QWKVKTTKQG FKTLIKPSIN SMKSQYKK.. .......MAE .......... N.sp.I4 QFPVGKYHSG KSSSGKLLGY KTLITPSKAK LKIHAQKIGK .......... B.a.I1 .......... ..QYPTKEGS QLFIKPSNQS VKKAKEKISE .......... B.c.I1 .......... ..QYQTEQGN KLFIKPSKGS RQKAKKKIGD .......... E.c.I5 .......... ......KYGG KMLIKPSKAN VSSFLKKIRA .......... A.v.I1 .......... ......KYGD KLLIKPAHRN VKAFLAKVKA .......... B.t.I1 .......... ......KYKG VLLIKPSQKS LKKFMQKIRG .......... B.me.I2 .......... ......QYNT GQGKKLFIKP SRDSIKKAKN .......... A.v.I3 .......... ......KYAG KLLITPARKS VKVLLEKVRE .......... B.f.I1 .......... .....VAAGG MVKRKVAAKP LLAFKHRIRE .......... B.f.I2 .......... .....VARGG TVKRKVAAKP LATFKQRVRQ .......... Ma.sp.I1 .......... ......KYRD KLLIKPSRKS ISNLLEKVRE .......... R.m.I1 .......... ......KYSG TLLIKPSRKN AQAFYRKVKE .......... Tr.e.I8 .......... .....QFNGS CFIVPQKEKV KEFLTLIRG. .......... P.p.I2 .......... ......KYQG KLLIKPANKS VKALLDKVRE .......... M.a.I1-1 .......... ......KYKG KLLPKPSKDS QREIIKKISD .......... M.a.I1-2 .......... ......KYNG KLLIKPSKKS IKRFTETISQ .......... M.a.I1-3 .......... ......KYRD KLLIKLLENP YKNLLKISQT .......... M.m.I1-1 .......... ......KYKG KLLPKPSKDS QKEIIKKIRD .......... M.m.I1-2 .......... ......KYKG KLLPKPSKDS QKEIIKKIRD .......... X.f.I1 .......... ......KYKG KLLIKPSAAS LKNCADKIRA .......... R.r.I1 .......... ......KYNG KLLITPSKHS VKALLDKVRR .......... P.p.I1 .......... .......... .......... ....MHQQPR LRVATMSLGR Sr.me.I3 .......... .......... .......... ..RGRDGAVK RRVADKPLNA S.p.I1 .......... .......... .......... ...KSSDGWK SRPHQDSVRR S.ag.I1 .......... .......... .......... ...KSPKGWK CRPHQDSVQS A.v.I2 .......... .......... .......... ..AAPKGQVK RKVAAKPLAT A.v.I4 .......... .......... .......... ..QNRDGEVR RGVSKKALEA D.h.I3 .......... .......... .......... ...IYRGEGR LRIHPQSIRK N.e.I1 .......... .......... .......... .......GKK IRWTEKSLAN N.e.I2 .......... .......... .......... .......GKK IRWTEKSLAN G.s.I1 .......... .......... .......... .......GTK ILWSDQAYKE O.i.I1 .......... .......... .......... ....NGKNPK IRIAKESIMR P.p.I3 .......... .......... .......... ....WHQQPR LRVARMSLDR B.h.I1 .......... .......... .......... ....RGKDPK MRVSKESVKR B.t.I3 .......... .......... .......... ...VKKGDCI LLVHSKSKNK A.g.I1 .......... .......... .......... .......ANR IHWHPKTLLK S.ma.I2 .......... .......... .......... ....YGQVQI HEQALKKFKA M.sp.I1 .......... .......... .......... ......WDGK LGLSRQSEQR C.a.I1 .......... .......... .......... ...QWYGKIG IRVHEKSVKK P.a.I1 .......... .......... .......... ....WHQQPR LRVARMSLDR P.a.I2 .......... .......... .......... ....VHRQPK LRIAGSSLQR S.t.I1 .......... .......... .......... ....RGKIQW HAKTLRIFKQ B.me.I1 .......... .......... .....AHLKK TKKRTLYVAR SHMTKNALKN C.d.I1 .......... .......... ........VK KGKANGYTNR SRMCDKAKIN B.a.I2 .......... .........A VKKGKKKNGD TRYIAVTHVS PKALEKTKQD En.fm.I1 .......... .......... .....MIPRR KKLVVKSHIS DKQFKNQKDK E.f.I3 .......... .......... .....VRKKG KKYVVRSHMS DKAYKKAHEK E.f.I4 .......... .......... .....VKQKG KNGFVIRIFL TKRKIKLKKR E.f.I1 .......... .......... .....LHKKG KKKVAFTYVC RKAEENIKNK E.f.I2 .......... .......... .....MVKKN HRFVCYSHVA LKARKRIKRQ N.p.I1 .......... .......... .......... ...VQRSGKF VCTPSVENYT Th.e.I1 .......... .......... .......... ...KYNGVLL IKPAKKNVKA Tr.e.I2 .......... .......... ......QYEV KSTNQGFKTI IKPSSKSVKT Tr.e.I3 .......... ......QYPV GKYTTGKNTY GKPLGYKTYI MPSKEEIKAH Tr.e.I4 .......... .......... ......QWKV KTSKQGFKTL IKPSKQSINT Tr.e.I5 .......... .......QYP VKDINCDTDR QGKKLRFKIL IKPSKEAIKR Tr.e.I6 .......... .......... ......QGQA KIAKLGFQTL IKLSARSIKT Tr.e.I7 .......... .......... ....QHKVSK NQSKLGFKTK IKPSTGMIRS Tr.e.I9 .......... .......... ......QWKV KTTKQGFKTL IKPSSKSIKT Sr.me.I1 .......... .......... ..PRRVANTQ RDEFFCGYTP AVSPTALKSM B.j.I1 .......... .......... ..P.RMAKNR WGRIFTCFLP GVSPNSLKEM R.e.I1 .......... .......... ..P.RKALSP QGGPFTSFLP GASESALKRM E.c.I1 .......... .......... .ARRARNQRS GN.LFTSFSP AVSNSAQKGM E.c.I3 .......... .......... ..VRTLKNFK GE.LYRKCMP GASNAAMRKI E.c.I2 .......... .......... ..RRVVKNVK RNSLFVSFTP AASKSALKAM P.l.I2 .......... .......... ..PRLSKNRW GKTFV.NFSP GMSARAGKAI M.a.I5-1 .......... .......... ..PRRSKNKY GKHFI.NFTP AVSNTAKKSM M.a.I5-2 .......... .......... ..PRRSKNKY GKHFI.NFTP AVSNTAKKSM M.a.I5-3 .......... .......... ..PRRSKNKY GKHFI.NFTP AVSNTAKKSM UMB .......... .......... ..PRLCLKSN GEKFW.GFRP AISKKSEKRI A.v.I5 .......... .......... ........CS TNRSGGFQIL RLTVKKRMRA B.j.I2 .......... .......... ........CG KSRRGRFQLQ RKTRGDRMRT P.l.I1 .......... .......... .......... .......... .......... Sr.me.I4 .......... .......... ........CG LTRDGRFIVK HKTEGKRLTR S.ma.I1 .......... .......... ........SG KDRNGRFMLI RKTRRDRMTA N.sp.I1 .......... .......... .......... ...VKPNGKF ISTPSQKATS N.sp.I2 .......... .......... .......... ...VQSNGKF NCTPSEENFK N.sp.I3 .......... .......... .......... ...VQQNGKF RCVPSEENYK Ma.sp.I2 .......... .......... ........QR MTLQGKQGVL CIPRMKARTS S.ag.I2 .......... .......... .......KSK SHKSGKYKTY YYPSRKSMKS

------------------------------------------------------ N.a.I2 RLRAKHRNHL ..LSCSDVEI VLAYNAELRG FANYYALARD VKFKLNRLEY N.a.I1 SFRPVGRAAL ..RFASDVEI VLAYNAEWRG FANYYAIADD VKRKLNKAGY L.l.I1 SWFPVHRKYL ..IRSTDLEI ITIYNSELRG ICNYYGLASN FNQLNYFA.Y B.t.I2 VWKSIVRTYM ..LNLDDLEI VSQFNAEIRG FYNYYSIANN SYVINSFYHI OYPI1 RGKIKHDETL ..ASRDELEI IRTYKTIVRG IIQYFCLANN LNALTHLTYL D.h.I1 SYKALHRGKL ..VNRSDIDI LTAYNQEIRG IRNYYRVANN SIKIGRYS.M D.h.I2 KWTPQPRTDF ..MGLEPREI VNMYNAQLRG IYNYFRMANN ASVLNKFH.Y Sr.me.I2 ......QRDS ..ISVSLGEK LRGVNAITSG WANYYRYCVG AGRVFVALDW E.c.I4 ....ALLWKV RISGEILLG. .......... .......... .......... S.f.I1 ....ALLSGN YSESKVDMAE QLNRKLKGWA MFYQF.V.DF KAKVFSYIDR C.sp.I1 .....IIDNH ..KNAAQETL ISKLNPVIRG WVNYYST.SV SKEIFSKLSH G.v.I1 .....IIHKH ..KAQPQSFL IEHLNPIIRG WTHFFSK.VV SGATFKKLDR T.sp.I1 .....IFDVM ..KAVPTKVL IAKLNPIIRG WSNYFST.VV SKEAFIKIDN N.sp.I4 .....LIDEH ..KAVPQSDL IAHLNPVIRG WTNYYSC.VV SKRIFNQADT B.a.I1 .....IFKSH ..RGRSIGQL IRKLNPVITG IANYWSP.VV AKVIYGDIDS B.c.I1 .....TLRVM ..RGQPIGEI IRVLNPIIRG YGQYWKH.VV SKKIFGTMDS E.c.I5 .....VIKGN ..KAMDQLTL IRMLNPMIKG WAAYHQ.HIV AKVAFNKVDN A.v.I1 .....LIEGN ..KTAPASLL IDKLNPVIRG WANYHR.PIV AKQTFNYVDY B.t.I1 .....IIDSN ..KGSKQESL IRLLNPVITG WVNYYK.NCV ASDTFRKADY B.me.I2 ...KIKDTFS VMRGRPVKEL IRVLNPIIRG YGQYWK.HVV SKKTYSYMDN A.v.I3 ...VVNGNKA ATQANLILIL TLTLNPIIRG WAMYHR.HVV AAARFAWIDH B.f.I1 .....LTRRS ..GGRSMKEV VERLRSYVQG WKAYFR.LAQ TPKVWRELEE B.f.I2 .....LTRRL ..GGRSMQDV VQRLRPYLLG WKAYFG.LAQ TPRIWRELDE Ma.sp.I1 .....IIKSH ..KSSTAGGL ILLLNPIIRG WANYHR.HVV SGRVFARVDH R.m.I1 .....VISAN ..KTVKQEVI IRLLNPMLRG WAQYHS.PVV AKEAFSKMQS Tr.e.I8 ....WLKAH. .PTSTQEAVI ANLNSIIRGW GNYYR.HGVS QRIFSYVDHE P.p.I2 .....IVKSN ..KSATQANL ILQLNPIIRG WAMYHR.HVV SKSLFSSIDA M.a.I1-1 .....VIHKA ..KAWDQDRL IRILNPIIRG WTQYHN.HTV SSEIFSKLDD M.a.I1-2 .....TITEG ..KAWSQEFL ISKLNPIIRG WANYHN.SVV SSDIFQTLDH M.a.I1-3 .....IKAG. ..KGWSQEFL IAKLNPIIRG WTNYHR.SVV SSETFHILDH M.m.I1-1 .....VLHKA ..KAWDQDRL IQTLNPIIRG WAEYHN.HAV SSAIFNKLDE M.m.I1-2 .....VLHKA ..KAWDQDRL IQTLNPIIRG WAEYHN.HAV SSAIFNKLDE X.f.I1 .....IVRSN ..KAANQASL IHLLNPVIQG WANFHR.HIV AKKTFKSLDD R.r.I1 .....IIKGN ..AAIAQEGL IQMLNPIIRG WAMYHR.HVV AKATFSSIDF P.p.I1 LRDRLRILLR SVRARKVATV IERINPVLRG WAGYFKLSQS KRPLEKMDGW Sr.me.I3 FKRRVRQLTR RSGGRSMAEV AERLRVYVLG WKAYFRLAQT PRLFKELEEW S.p.I1 FKLKLKKLTQ RKWSIDLTRR IEQLNLSIRG WINYFSLGNM KSIVASIDER S.ag.I1 FKRKLKQLTM RKWSIDLITR IERLNWVIRG WINYFSLGNM KSIMTQIDER A.v.I2 FKQRIRQLTR RSGGRSMAQV VQELRPYVLG WKAYFGLSQT PRVWRSLGEW A.v.I4 FKQRIRC.TR RNGGRSLAEV IEKLRRYLPG WKGYFSLAQI PRVWRRLDEW D.h.I3 LKDKIREVTG RSNGMGIEER KTKLNQVVRG WTNYFKLADA KSQLKEIDEW N.e.I1 FKHRVRQLTG RSWGVSMEYR LEKLGQYLRG WFGYYGISQY YRPIPELDEW N.e.I2 FKHRVRQLTG RSWGVSMEYR LEKLGQYLRG WFGYYGISQY YRPIPELDEW G.s.I1 FRRRVRKYTG RSWFVSMEYR LNKLSTYLRG WMGYFGIAEA YRDIPEIDGW O.i.I1 LKQKIREITS RSKPFPMEVR IEKLNKYLMG WCGYYALAET PSKFEEFDKW P.p.I3 LRDRLRMLLR SVRARKMATV IERINPVLRG WASYFKLSQS KRPLEELDGW B.h.I1 LKQRIRELTS RRHSMKMSDR LRRLNRYLTG WLGYYQLVDT PSILAQIDAW B.t.I3 MKSKLKELTS RSNGWGYEKR KQKLKDYIRG WIAYFCLAQM KRLCIETDEW A.g.I1 FKQNVRKLTN RNWGVSMKYQ LFKISQYLRG WINYFGIASG YQHCVELDHW S.ma.I2 NVRELTNRNW GI.SMTL.QI HKLTQ.YLRG WGHYYLIANA YQLTVDLDHW M.sp.I1 FKEKVKKVTR RNRGISLEQM VKELNRVLRG WLNYFRSAKM LSKLQRLSSW C.a.I1 FKAKIKAITA RSNALNIENR IIKLRQCIIG WLNYFGIAEM TKLAKKLDEW P.a.I1 LRDRLRMLLR SVRARKMATV IERINPVLRG WASYFKLSQS KRPLEELDGW P.a.I2 LRERVKSLLR ARRGSQLTWL IERLNPVLRG WSSYFKLSQS KRPVEELDGW S.t.I1 KMRRLTNRNW ...GVSMGYQ LFKVRQYMQG WINYFGIANA YQGCVDLDHW B.me.I1 AQIKVKQTIK EIQKHQSVEN VWHFNTVIMG IQNYYSAASH ITDDLTELNY C.d.I1 AVDKTKDNIK TIAANPTVDN VNKYNSVVLG LHNYYKIATL VNLDFVDIAF B.a.I2 LAKQVRRIQK TPNSNETIKR ISIYNSMVIG KHNYYKIATH ASQDFSKMNH En.fm.I1 LVSQAKKIAS PSKGKTELEE TRLYNSMVLG MQNYYQIATN VNLDCMKLNR E.f.I3 VSEEVKKLAY SSDDNAQFMQ LQKYNSVVAG LHEYYCISTE VSHDFSRLAF E.f.I4 LNKELKIFKR ALQHKMLSYL MLXMNYVLSF TTY....... .......... E.f.I1 LKQQIKKIQY AGAKKNRHRA IGDYNMMVIG IHNYYRIASH CSVNFTEIYR E.f.I2 LKDQIKRIQR KKSKITTIRE IQKYNSMVIG IHNYYNVATH VSKDFESIGS N.p.I1 AFRKKVKSIA NTSHYGAETK AQKIAPIVRG WRNYHDRCNM DSTKDSLWFL Th.e.I1 FLKKIRDTLR ELRTATQEIV IDTLNPIIRG WANYHKGQVS KETFNRVDFA Tr.e.I2 HYRKLADRCD KNKTAPAKAL IAKLNPIIRG WANYFSAIV. .SKSTFNKLD Tr.e.I3 YQRLASEIDK FKSCKSQIDL IKGLNPIITG WSNYYSKVN. .SAKTFKELD Tr.e.I4 HYRKMAEVCD THKSATVKVL ITKLNPIIRE WANYFSAVV. .SNDIFQKLD Tr.e.I5 HTRVLKHTIR LYRNASQEKL IEILTPKIRA WSNYYVVDKY WGVDKGKGWK Tr.e.I6 HYRKLAERFD SYKIAPVKGL IAKLNPAISG WVNYFSTQVS TNKIFNKLDM Tr.e.I7 HYCHIAEVID KYKSASQAVL IRKLNPIVKS WVNYYSKLFV .SKKIFQDLD Tr.e.I9 HYRKLADICD KHKNAPTKAL IAKLNPVIRG WANYFSTII. .SKETFSKLD Sr.me.I1 RATIKSLNIP RQTPGTLAEI AKQLNPLLRG WIAYYGRYSR SALSTLADYV B.j.I1 RARIRGWRLP QHSPLPLEDI ARSLSPVLRG WDQYYGRFYP TELRRLYEYF R.e.I1 RQAVRGWRLN RQTHVTLADV ARLYNPVIQG WWNYYGAFYK TAMLHIFQHI E.c.I1 IEKLRKLRLR RRVEMSLEDI AKRLNPMISG WLNYYAKYHK DILI.LTLI. E.c.I3 TETIKKWRIH RSTAESLLDF ARRYNAIVRG WIGYYGKFWS RNFNYRLWSA E.c.I2 RREIKATGIR KRVDLSIEQI AKWINPKLNG WINYYGRYTC SELYSVFRYI P.l.I2 RQEVRSWGLQ NRSDKSLYDL AHMFNAKIRG WINYYGAFYK SALYPTLRQI M.a.I5-1 QQEIHNWRMH LKPDLTLEDL SHMYNPIVRG WVNYYGLFYK SELYCVLKHM M.a.I5-2 QQEIHNWRMH LKPDLTLEDL SHMYNPIVRG WVNYYGLFYK SELYCVLKHM M.a.I5-3 QQEIHDWRMH LKPDKTLEDL SHMFNPILRG WVNYYGLFYK SELYCVLKHM UMB LGELRKLKIH RWIYMNIHQV SQRLRAKVRG WLNYYGRFRK SELSWIFRHL A.v.I5 TLQAIRIALN RRRHEPIRVV GQWLGSVVGG YFNYHAVPGN LIRLDGFRVA B.j.I2 KLREIKEELR RRMHWPIPAQ GRWLRQVLTG HFAYFAVPTN GRALNAFRFY P.l.I1 ...IGRLHTG KDAVMQGLRQ RLQTARKKRA GGNEWKDTSI TMASPSTVEH Sr.me.I4 KLKALREGAW RHMHRSLATQ HKWLAAVLRG HYGYYGRPHN YPALNGFYQQ S.ma.I1 TLKAIKDGLR RRWHYSIPEQ GKWLRRVVQG YLNYHSVPGN FPTMQKFRTH N.sp.I1 SIKAKVKEVM KDSCFTLEER IDKCGAIVRG WRNYHRFCDM SQHNLWAIAY N.sp.I2 KFRQKVKAIV NCSNYGSSVK AEKLAPIVRG WRNYHRFCDM SGSRFSLWFL N.sp.I3 AFRKKVKKIV NCSNYGAKVK AEKLAPIVRG WRQYHKFCKM DGSRFRLWHT Ma.sp.I2 LLGRLKEVFK HLRSQPTEWV VNTINPILRG WVSYFRIGNS SRSFNFVRNW S.ag.I2 IKGKVKDVIQ TGQHLNLPDV MERLNPMLRG WANYFKAGNS KQHFKSIDNY

Domain X -------------------------------------| N.a.I2 LQRWSMFK.T LASKHK.SSV RVVAARMRQG LEYLAGYEVG GQPRSVKVWK N.a.I1 FALLSCVK.T IAGKHR.TSA RRVFAKLRRG TDFYISYEVG DTTRTIKLWQ L.l.I1 LMEYSCLK.T IASKHK.GTL SKTISMFKDG SGSWGIPYEI KQGKQRRYFA B.t.I2 MSYSMYKVFA NKYKSSVKKI LLKYKKNKVF QVAYENSKGK TLYQSFYHDG OYPI1 AEYSCLKTLA RKRKTTIAKV RKKFNRSSTW SIPYLNKEKT RYESWTVYPW D.h.I1 LKTFARKYRT SVSRIKARYV MKKTFMVEYT IKSGKRVATF YNGGFHRERL D.h.I2 VMKYSL.YKT LAGKFRTTVS KINAKYSRDG AFIVEYMTKS GIRRVTFYQD Sr.me.I2 YIGLRLYC.W LHKKRPKATP SELWGSKQPS RRRATRRVWR EGSVEQHVLG E.c.I4 .......... .......... .......... .......... .......... S.f.I1 VVFWKLA.HW LARKYRTGIA S..LMRWWCK SPKPGQSKTW VLFGKTNHGK C.sp.I1 LIYQKLK.RW GKRRHPDKSN VWVTKKYWHT VGGD.NWVFA ATKNGEITM. G.v.I1 TLYMQLK.AW ATSHHRNQSQ KWLARKYWLT IGTQ.NWCFA VQKGEGIK.. T.sp.I1 LLWKRLG.RW ANRRHSNKSA AWVKSKYFPA LGSR.NWILN D...GEY... N.sp.I4 TLFSQLK.AW AEHRHPNKSS RWSCQKYWQT VGSD.NWVFK PHNQKI.... B.a.I1 YVHKKVM.HH LKYKHHRKGA RWINKKYFHP DHTGVSQDKW LLTDPDNHKN B.c.I1 YIYWRIG.KH LRQLHPKKSW KWIYARYYRH PHHGGNA..W TPTCPKTNI. E.c.I5 EIWLALW.RW AVRRHPNKGK KWIRKRYFHQ QGARNWSF.S TATGELLANG A.v.I1 RIWKLLW.RW CRRRHGNRCK RWIKEKYFKR IGTRSWVF.S GRYPSGKLAT B.t.I1 LIFEKLW.QW ATRRHPKKGK YWIADRYFTR VKNRNWCFVA NFKKGKTDDR B.me.I2 YIFLKVR.KH LKQLHPKKSR KWISKRYFKK PHHGGNNKWI LTCPLTNIQL A.v.I3 QIWRILW.RW AVRRHAMKSA HWVKQRYFRV VGRRHWVFAC KERKHGMSQP B.f.I1 ..WMRHRLRA IQLKHWRRGP AIYRELRGLG APEPVAKQVA ANSRRWWRNS B.f.I2 GL..RHRLRA IQLKQWKRGP TMFRELRALG ASPAVAQRVA ANSRCWWRNS Ma.sp.I1 AIWQAIW.AW AVRRHPKKSK KWVRSKYFTT EGGNNWAFFG ETYAGVRVLL R.m.I1 RVFRALLWWT KRRHRGKNAE .WVRKKYFAS FGDRNWVFGT EFVEDDGERR Tr.e.I8 IWKSLW.QWS LRRHSKRVGK QKGKGKEWVR KKYFKTVNGN KWTFATNISN P.p.I2 QIWRLLW.TW ALRRHPNKGA GWVRQRYFHT VRYQNWVFRA QTKVGGIVQR M.a.I1-1 TVYNMLI.SW AKRRHSNKGL TWIMTKYWHK SGSRKYVFCT ELKTLERFSN M.a.I1-2 RIWELLW.KW AKRRHLNKPK DWIVNKYWKR STTRRWNFRT EKNNLLLLSK M.a.I1-3 IIWKMLW.NW VKRRHPNKSQ KWIVNKYWKP NNTRRWNFKT ESNELLLLST M.m.I1-1 IVYNMLI.SW AKRRHSNKGF TWITTKYWHK SGKRKYVFCT ELQTLERFSN M.m.I1-2 IVYNMLI.SW AKRRHSNKGF TWITTKYWHK SGKRKYVFCT ELQTLERFSN X.f.I1 HVWRALW.KW ALRRHPAKGK KWIRHRYFHA .RGRQWVF.. AARYVDSSSK R.r.I1 YIWRMLW.RW ACRRHPNKGA RWIRRRYFRV NGSQSWDFST EDAKYGLVRA P.p.I1 VRHKLRCVIW RQWKRPSTRA RNLMRLGLSE ERAYKSAFNG RGPWWNSGAS Sr.me.I3 MRHRVRAIQL KHWKRGKTTY KALLAKGAKP EAARQIAVNS RRWWRNSGML S.p.I1 LRTRLRMIIW KQWKKKSRRL WGLLKLGVPK WIADKVSGWG DHYQLVAQKS S.ag.I1 LRTRIRVIIW KQWKKKAKRL WGLLKLGVAR WIADKVSGWG DHYQLVAQKS A.v.I2 LRHRLRAVQL KQWKRGKTLF RELRALGASH EVAQRIAANS RRWWRNSGKL A.v.I4 IRRRLRALQL KQWRRGKTIY RELLRLGAKQ GVAQSVAALS RRWWHNSLSA D.h.I3 MRSRIRMVAW KQWKRIRSRY DYLKKAGVSK EKAWMWANTR KGYWRTAHSP N.e.I1 IRRRVRMCYW KQWRWARTKI RHLLDLGIPL KAAIQHGVSS LSYWRMARTP N.e.I2 IRRRVRMCYW KQWRWARTKI RHLLDLGIPL KAAIQHGVSS LSYWRMARTP G.s.I1 IRRRVRLCYW KQWRWCRTKI RNLLKLGVQL GTSIRAGLNR NGPWAMSRRL O.i.I1 IRRRLRMCMW KQWKLPRTKV RKLISLGVPD HKAYEWGNTR KNYWRISKSP P.p.I3 VRHKLRCVIW RQWKQPPTRL RNLMRLGLSE ERANKSAFNG RGPWWNSGAQ B.h.I1 IRRRLRMIRW KEWKTTSARQ KNLVRLGIKK AKAWQWANSR KGYWRVAHSP B.t.I3 LRRRIRMCIW KSWKNAKTRV ANLKKCGVSE WQAYQWGNTR LGYWRVSNSP A.g.I1 IRRRVRMAYW RQWRKPRTKV RNLMRLGVHV QAAVACGITS KGPWRSSKTP S.ma.I2 IRRRIRMCYW RQWRKPRTKV RSLMKLGVSE RLAIACGITS KGPCRSSKTK M.sp.I1 IHRRIRCFRL KQCKRAIGIT RFLVSLGLPK WRSLLLATSH KGWFRKAGSP C.a.I1 TRRRLRMCYW KQWKKVKTKY DNLRKFGINN SKAWEFANTR KSYWRIANSP P.a.I1 VRHKLRCVIW RQWKQPPTRL RNLMRLGLSE ERANKSAFNG RGPWWNSGAQ P.a.I2 VRRLLRNVLC GTGNDRLPGH A.IMRLGLPE ERAWKSATNG RGPWWNAGAL S.t.I1 IRRRIPYVLL ASVAKTTDGA K...FTAWRQ DQAGVCGITS KGPWRSSTPG B.me.I1 RLHKAL.... .FNRLKELRK EATFQDFPKS LQKRYKGYEC KYFKIKEMVL C.d.I1 TVNKSL.... .DCRTKNIRN K..HGTLTST YQKFYKQYNW KKRFIANMIL B.a.I2 NLDHIMYNRF PKSTMEVKAT QMDTRIGEYK GKDKGIKPYL KLKMTRFLMK En.fm.I1 AVMAIF.... .TNRLGTNKR G..RLRKTGR QLTTKEATRY GKSKMLRYVA E.f.I3 SINKQL.... .RNRLKGDL. .....SKKGQ LRNGFIKEKY GASRQMRFLH E.f.I4 .......... ..NRLSNCST RCYPNKASPT YKKFYSTTMK TYKVAGVYLY E.f.I1 SVRTVIEARL KARGMTKNGI YGQDHEGYRP YLKSKQMRYI EGFPILPIGY E.f.I2 QLHRSF.... .YNRFRNKGL T...KKGNYK GHDKGIQPYM ESKRIQYLVN N.p.I1 NHATFKKFLA EKKMTKYRAE A......LVK KAFPSVSWTE GKF....... Th.e.I1 TWHKLWRWAR RRHPNKPAQW VKDKYFIKNG SRDWVFGMVM KDKNGELRTK Tr.e.I2 MLLWKRLGRW A.SRRH.... ........SN KSAKWVKEKY FPRYKETRNW Tr.e.I3 HLLTLKLIAW GKSRHH.... .........H KSIKETIKKY FGTKGKS.NW Tr.e.I4 HLLLRRIWRW A.SRRH.... ........SN KSAAWVKEKY FPHREGTKSW Tr.e.I5 FITSEGKQLR WHKDTPIKRF VRLQENKSPY HEDWAHIQGP SSYIVVKREV Tr.e.I6 LLWKRLWCCA SRQHPNNSAT WVKQEYFPNI ENGNWILPRG EYMLNQYSDV Tr.e.I7 NLIFQKLWGW AK.RRH.... ........PN QNNHWIYQKY WQSIGENKRE Tr.e.I9 YLLWRRLGRW T.SRRHPKVS QMGQEEVLPN KSAKWVKKKY FPRCKVTRNW Sr.me.I1 NQKLR...AW IRRKFKRFQS HKTRASLFLR KLARENPGLF VHWKAFGTNT B.j.I1 DERLG...AW LRCKYKQLKG HRGRSLRKLN EMAKQNPKLF VHWQKLGRAT R.e.I1 DCALE...RW ARRKYKGLHR RKRRSAEWLD RMRRNNPMLF AHWRVVTQPA E.c.I1 ........AW ARKKYKTLRY RKTKACQLME RLSKEKPELF AHWNAGPESA E.c.I3 MQSRL..LKW MQSKYRLSNR KAQRKLTLVR KEYPKLFVHW YLLRASNE.. E.c.I2 NKALV...RW GRKKYKMLSR YKTRASKFLE EMAKRSPQLF AHWRLKMRGG P.l.I2 DRKLV...LW LTRKHKRLRG HRRRASHWLA RVARSETRLF AHWPLLWGQA M.a.I5-1 NRALT...RW ALRKYKKLSG HKRRARYWLG KIARRDPKLF VHWQMGIFPE M.a.I5-2 NRALT...RW ALRKYKKLSG HKRRARYWLG KIARRDPKLF VHWQMGIFPE M.a.I5-3 NRVLT...RW AQRKYKKLAG HKRRARYWLG KIARRDPKLF VHWQMGIFPE UMB NIRIS...KW ARNKYKLKTY SKSYGWLKRM VKWYPNTSLH WEHGFTG... A.v.I5 VCRLWRQALK RRSQRNRLQW SRYGRLADLY IPRPRTAHPY PEERFASRT. B.j.I2 LTDLWR..RT LRRRSQRTCL TWDRITQITD DWLPKARILH PWPKLRFAVK P.l.I1 CVNLWK..KS CGSHDGEASG TKRGLVTVSG KWIPSPRTVH PYPLQRFYAK Sr.me.I4 TRAYGSAA.. .......... .......... .......... .......... S.ma.I1 VTNLWR..RA LRRRSQKDDT TWTKANKLAA AWLPRVRVLH PWPVERFTAR N.sp.I1 WTWKFIRKQG RYNRDQTNQV IHRAFPAVKW AACRFNNVTE ..DKSPYDGD N.sp.I2 SKRTHTVFNK ETKNDHESSI KLAQKAFPKV PCFQNSYVMV KGDKSPYDGD N.sp.I3 RDRAFRVFNK ETKQDRHSAE KLTQEAFPTV PYSENAHIKV KGNKSPFDGD Ma.sp.I2 VERKMRRHLM RARVRRGFGW NRWSRDWLYK SLGLFGDYRV VYYQPKSTTS S.ag.I2 VIYNLTIMLR KKHKKSGKGW REHPPSWYYN YFGLVCLRKL STNINDDSQR

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N.a.I2 MTDLNRDRID PDKVDVQPWT QIFSGSRTDW V......... .......... N.a.I1 LKDLQRHTRT WGGIDIPSSA KFVFSRTELV .......... .......... L.l.I1 NFSECKSPYQ FTDEISQAPV LYGYARNTLE .......... .......... B.t.I2 FKRKKVAGNI YCDTIPRT.V SITGGRNSLM .......... .......... OYPI1 DKIKKMRNYK ENPDITIN.P YLFQGRTNLT .......... .......... D.h.I1 AINDARVSLL PQYTRYEKR. ......NSFT .......... .......... D.h.I2 GFPRIVAPLP ANVDYQPEYV VNYEPKELF. .......... .......... Sr.me.I2 WTPVDRYRLA WMDMPDFAMS SGEPDA.... .......... .......... E.c.I4 .......... .......... .......... .......... .......... S.f.I1 LSGEILYRLV GQGKKLFRWR LPEGNPYLRT ETRNTYTSRF TEVAMAFASI C.sp.I1 RLFKHSQKEI VRHVKVKGDA SPFDGNLKYW SSRKGENPLV PKRVAIL... G.v.I1 RLVQHSDRPI TRHVKVKERR SPYDGDWVYW SNRIGQHPQI KAEVARL... T.sp.I1 VLNQHSNVSI VRHVKVKGNN SPYNGDWTYW GNRLGKYPGI RKEVTTL... N.sp.I4 RLLKHRETRI VRHIQVKGSR SPFDGDWVYW SSRMGKHPEA PIRVATL... B.a.I1 QLIRMRWTPI VRHVLIKYKN SPDDANLKKY FAKRDEKIFN RFNTNSKRKL B.c.I1 QLLHMSWIKI ERHNMVKFKN SPDDPTLKEY WEKRDRKVFD TENTMDRMKL E.c.I5 KPQYANLRKA IDTPINRFKP IKIAANPFDP QWEMYFEERC ADKMRHKLQG A.v.I1 LL.YADDTTI QRHKKIRAEA NPYDPEDEMY FEERLEYAWR RSDEGKRKTL B.t.I1 IALKRLYDTK ITRYVKVKGE ANPFAPEWTE YFEKRKTYKM LQSLNGRKSL B.me.I2 LKMSWIKIER HVMVAYKNSP DDPSLREYWE KRDRKVFNTE NTLDRMKLAR A.v.I3 VWLFAAASVP IIRHVRICSA ANPFDPAWTL YLERRRAQRQ VARSPGCWKA B.f.I1 DRLLKSVLTI AYFDRLGVPR LS........ .......... .......... B.f.I2 DKLLNSVLTV AWFDRLGLPR LS........ .......... .......... Ma.sp.I1 FKATSLGIIR HIKVRQDLNP YDPAWKDYLV KRVAKSTPGS GWVPQGAF.. R.m.I1 WQELYSLAST PIRRHKKIRG DFNPFDPAQE MYGENLRRDR MLESMSHRKQ Tr.e.I8 RYGKKETIAI CRLGKVPIQR HVKIKGTAPE NPSLTKYLKR YTKYDKAHRV P.p.I2 WWLFRASTIP IVRHVKIRGL ANPFDPAWSS YFARRRSAMD VD........ M.a.I1-1 SKVVRQRLAS LNKNPFIDKE YFEQWKFMEY HRKKRITNPI LF........ M.a.I1-2 TRIYRHIPLK LQMNLFLNVD YFYERQNKLN PRKGQSIKKD CYLIQKRL.. M.a.I1-3 TRIQRHIPLK IKMNPFFDND YFHERQNKLK FRKECHKKQL LPDTERVIEC M.m.I1-1 AKIVRQRLAS LNKNPFIDKE YFEQWKFMEY HRKKRITNPN SVLN...... M.m.I1-2 AKIVRQRLAS LNKNPFIDKE YFEQWKFMEY HRKKRITNPN SVLN...... X.f.I1 EARWATLRKA VDTKIRRNTM IRMGANPFDP EWETYFEQRL GAKMKDNLQG R.r.I1 AAVPIKRHAK IPALANPFDP TWDDYLARRQ DAKHTAGEPG VTTWRWRMA. P.p.I1 HVNQALPKKL WDRLGLVSIL DTINRLSRVT .......... .......... Sr.me.I3 LNSVLTLRWM DALRIPRLA. .......... .......... .......... S.p.I1 VLKRAISKPV LEKRGLVSCL DYYLERHALK VS........ .......... S.ag.I1 VLTRAISKPA LAKRGLVSCL DYYLERHALK VS........ .......... A.v.I2 LNSVLNLAWF DRLGLPRLA. .......... .......... .......... A.v.I4 GHNVLTIAYF DRLGLPRLS. .......... .......... .......... D.h.I3 ILRIALPNKR FEQAGYLSFT GCYSAK.... .......... .......... N.e.I1 VTQQAMSNDW LRAQGLLSIK DLWCKAQSYG PDKG...... .......... N.e.I2 VTQQAMSNDW LRAQGLLSIK DLWCKAQSYG PDKG...... .......... G.s.I1 AAQHGMTNQW LKDQGLVSVK ELWVKIHYPA TAR....... .......... O.i.I1 ILSRTLGNSY WSRLGLKSLY QRYEFIRNT. .......... .......... P.p.I3 HMNYALPKKL WDRLGLVSIL DTINRLSRVT .......... .......... B.h.I1 IMDYALNSEY WKGQGLMSLA ERYQTRRWT. .......... .......... B.t.I3 IVTFVMSNDK LRKAGYMEFM DCYLKWCPK. .......... .......... A.g.I1 GINQALSNAY LKSQGLYELR DGWIKLHHS. .......... .......... S.ma.I2 GINIALGNNY LASQGLVSLR DIWINIHYGR .......... .......... M.sp.I1 QAHEGMNKEW FRQIGLFNLV EYYSLNFKET A......... .......... C.a.I1 ILSTTLTNSY LEKIGYTSIF KRYKQVH... .......... .......... P.a.I1 HMNYALPKKL WDRLGLVSIL DTINRLSRNL NRRVRNRTHG GVRGRRV... P.a.I2 HLRQALPKKR WDALGLVSIL DTITRLSRMA .......... .......... S.t.I1 IQQALSNGYL KKQPLSLEMD G......... .......... .......... B.me.I1 IPIHAQRCKI NLNFS..QII CN.YTTVGRD KIHQNLRAIN KQTLTRVMKQ C.d.I1 FPIAGIKFTM PRIFPK...D WNRYTPEGR. LFIHQRLKMD MHTVYYLLEN B.a.I2 RPILPISYIQ HKNPMMKKQA INKYTAEGRA LIHKNLADIT EAELKWLREN En.fm.I1 GEGEPI.FPV GYIQH.RKPM AKVYLANCYT LEGRKFIHTN LSVDKLLMYQ E.f.I3 GR..PV.VPL GYVQS.KNAQ HKRKSINKYT VKGREQIHKN LAIDTATMLW E.f.I4 PLCDVSTKTI YGFNTEDTPF TPFGRQRLEH KSLQSLVYQE LRKLMESKIL E.f.I1 IKKRTPLNKR RNLNKYTKEG RKLIHQEQQA IESWKIKYLV KGFSNNKKYT E.f.I2 FPPFLPNRIW KNQNP.SKGR KKTLNKYTAL KVGNLYTKIN NPVAEWKVQW N.p.I1 .......... .......... ....VCVKGG KSPFDDDIAY WSKRQCKLYF Th.e.I1 RLIKTSDTRI QRHVKIKADA NPFLPEWAEY FEKRKKLKKA PAQYRRIRRE Tr.e.I2 ILNDGEYILN QHLDVPIIRH ....VKVKGN KSPLDGNWTY WSSRIGKHPG Tr.e.I3 IFKTIENGNR ICLVYHEDFQ IKNFVKVKGE SSPYDGNLIY WTTRMGKSAE Tr.e.I4 VLKDEEYILN LHSDVSIIRH ....VKVKDN KSPYDGDWIY WSSRMVNSPG Tr.e.I5 AILTVSSTLL RRIVWRWIIL FCSQKEEGTI WAVNS..... .......... Tr.e.I6 PIIGDIKVKD NNLTLDGDWN YWTSRVGKYS GVKTETSKLF KSQKNKCAFC Tr.e.I7 FFGSDKNGSQ VRLL...... .......... ...RHANLIY WSIELA.... Tr.e.I9 ILNDGEYILN QHSDVAIVRH ....VKVKGN KSPLDGDWTY WSSRIGKHPG Sr.me.I1 FT........ .......... .......... .......... .......... B.j.I1 VG........ .......... .......... .......... .......... R.e.I1 G......... .......... .......... .......... .......... E.c.I1 FA........ .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 LV........ .......... .......... .......... .......... P.l.I2 SMGRAG.... .......... .......... .......... .......... M.a.I5-1 AG........ .......... .......... .......... .......... M.a.I5-2 AG........ .......... .......... .......... .......... M.a.I5-3 AG........ .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 HPR....... .......... .......... .......... .......... P.l.I1 HPR....... .......... .......... .......... .......... Sr.me.I4 .......... .......... .......... .......... .......... S.ma.I1 HPRQEPGA.. .......... .......... .......... .......... N.sp.I1 FVYWSKRENV NYDGVTARLL KKQNHKCTEC NLSFISGDIA ELHHIDGNHD N.sp.I2 LTYWSERNSK LYDGETSKTI KKQNHTCGYC GLKCTSEERV HLHHIDGNHK N.sp.I3 LTYWSKRNSK LYDGRTSKLL QKQHHTCGYC GLSMLSDERV HLHHIDNNHN Ma.sp.I2 R......... .......... .......... .......... .......... S.ag.I2 YGR....... .......... .......... .......... ..........

Domain En |---------------------- N.a.I2 .......... .....DRQNA TQCEACGRSD ....LPCHVH HVRGMADVA. N.a.I1 .......... .....ERLNA RECERCGSND ....QPCEVH HVRRIGELQ. L.l.I1 .......... .....NRLKA KCCELCGTSD ..ENTSYEIH HVNKVKNLK. B.t.I2 .......... .....ERLKL QVCELCGATD .....KLEMH HVRKLKDLK. OYPI1 .......... .....DRLKA EICEKCGKTT .....QLQIH HIGTVRNEN. D.h.I1 .......... .....NRIRL HKCELCEKTS ..GQLTF..H QVKKLKELK. D.h.I2 .......... .....YRMKA ARCELCGKEH ..VLVSS..H QVKRLKDLT. Sr.me.I2 .......... .......... .......... .......... .......... E.c.I4 .......... .......... .......... .......... .......... S.f.I1 .......... .......... .......... .......... .......... C.sp.I1 .......... .....LKKXL GKCSHCGLYF R.EDDLIEID HIIPKSQGG. G.v.I1 .......... .....LKSQT GKCTHCGLYF M.NGELLEVD HRKPKRFGG. T.sp.I1 .......... .....LKRQK GKCAHCGNYF RPDDQMGSRP YKTKISEGG. N.sp.I4 .......... .....LKMQK GKCTHCGLFF H.HEDLMEID HKIPRSQGG. B.a.I1 .......... .....AKKTK YKCRVCNNSL V.GEEPLESN HIVPKVIGG. B.c.I1 .......... .....ARKQG YRCAICKTPL QNGEKVVVKD MPVPQHLIL. E.c.I5 RKKLIQI... .....WFEQR GRCPICDERI T.SDSQWQVH HIIRRVDGG. A.v.I1 RL........ .....WLGQS KRCPMCKQLI T.FETGWNIH HIIKRHMGG. B.t.I1 LYM....... .....WERQN HLCPVCGKPI DKEHPWGTSQ QTVNGKKVNN B.me.I2 .......... .......KQG YRCALCKQTL QNGETITVRN LKVSTGKFAK A.v.I3 .......... .......... .......... .......... .......... B.f.I1 .......... .......... .......... .......... .......... B.f.I2 .......... .......... .......... .......... .......... Ma.sp.I1 .......... .......... .......... .......... .......... R.m.I1 WIRL...... .....YVDQR GLCAVCQCKI T.KETGWDDH HIVYRTHGG. Tr.e.I8 KVQNTTKLPK LRAGNVPMSG EH........ .......... .......... P.p.I2 .......... .......... .......... .......... .......... M.a.I1-1 .......... .......... .......... .......... .......... M.a.I1-2 .......... .......... .......... .......... .......... M.a.I1-3 LSGMTRENVT YRS....... .......... .......... .......... M.m.I1-1 .......... .......... .......... .......... .......... M.m.I1-2 .......... .......... .......... .......... .......... X.f.I1 RKRLLHP... .....WLEQD GKCPVCDEPL T.KESGWHVH HIVRRVDGG. R.r.I1 .......... .......... .......... .......... .......... P.p.I1 .......... .......... .......... .......... .......... Sr.me.I3 .......... .......... .......... .......... .......... S.p.I1 .......... .......... .......... .......... .......... S.ag.I1 .......... .......... .......... .......... .......... A.v.I2 .......... .......... .......... .......... .......... A.v.I4 .......... .......... .......... .......... .......... D.h.I3 .......... .......... .......... .......... .......... N.e.I1 .......... .......... .......... .......... .......... N.e.I2 .......... .......... .......... .......... .......... G.s.I1 .......... .......... .......... .......... .......... O.i.I1 .......... .......... .......... .......... .......... P.p.I3 .......... .......... .......... .......... .......... B.h.I1 .......... .......... .......... .......... .......... B.t.I3 .......... .......... .......... .......... .......... A.g.I1 .......... .......... .......... .......... .......... S.ma.I2 .......... .......... .......... .......... .......... M.sp.I1 .......... .......... .......... .......... .......... C.a.I1 .......... .......... .......... .......... .......... P.a.I1 .......... .......... .......... .......... .......... P.a.I2 .......... .......... .......... .......... .......... S.t.I1 .......... .......... .......... .......... .......... B.me.I1 FIPSRS.... ..IEYNDNRI SR......FI AQYGKCAVTG VEL..GLDEW C.d.I1 SNPNKS.... ..VEFNDNRI SL......FI AQQGKCHVSG ENL..SKDNM B.a.I2 PV.I...NER ATVEYNDNRI SLYVAQKGKC SVTGEKLLPW ........DI En.fm.I1 LMKL.SLENR T.IEYADNRI SLFSAQHGKC AITLEEFQQA .......NEI E.f.I3 LMRN.PVKGR T.IEYADNRI SLYAAQYGKC AVTGIPM.NS .......HDI E.f.I4 ........NR M.VEYLDNRI SRYSMKSGKC EITKQFL.PA .......KAV E.f.I1 .......... ..VEFSDNKI SKFISQKGKC AITGNELLME ........EI E.f.I2 LREHPIINER ATIEYNDNRI SLFIAQKGKC AITGNELFL. .......DDM N.p.I1 GETA.TALR. .......... ....KQNHIC GYCGLNFLPG DDINLHHKDG Th.e.I1 LWKKQGGICP VCGGEIEQDM LTDIHHILPK HKGGSDDLDN LVLIHANCHK Tr.e.I2 VRKEVTTLLK .......... ....RQKNKC AFCGLTFRSN DQMGSRPYKT Tr.e.I3 PTKVAKVLKK .......... .....QSGKY TECSMYFTR. .......... Tr.e.I4 IRKEVSTLLK .......... ....KQKGKC AFCGLSFRPT DTMEVYHVIP Tr.e.I5 .......... .......... .......... .......... .......... Tr.e.I6 GLTFRVTDLI EVNYVIPKFK GGDNILRNKQ LLHQYCHETN IALNHKSYLI Tr.e.I7 .......... .......... .......... .......... .......... Tr.e.I9 IRKEVTTLLK .......... ....RQKNKC AFCGLTFRLT DLMEIDHIKP Sr.me.I1 .......... .......... .......... .......... .......... B.j.I1 .......... .......... .......... .......... .......... R.e.I1 .......... .......... .......... .......... .......... E.c.I1 .......... .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 .......... .......... .......... .......... .......... P.l.I2 .......... .......... .......... .......... .......... M.a.I5-1 .......... .......... .......... .......... .......... M.a.I5-2 .......... .......... .......... .......... .......... M.a.I5-3 .......... .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 .......... .......... .......... .......... .......... P.l.I1 .......... .......... .......... .......... .......... Sr.me.I4 .......... .......... .......... .......... .......... S.ma.I1 .......... .......... .......... .......... .......... N.sp.I1 NWKPNNLEVL HRECHQHQTI HGQVRVRTVG .......... .......... N.sp.I2 NRKPKNLIVV HESCHDYIHM GKRVTP.... .......... .......... N.sp.I3 NWKDSNLIVV HESCHDYIHM SKRGSEIYPI P......... .......... Ma.sp.I2 .......... .......... .......... .......... .......... S.ag.I2 .......... .......... .......... .......... ..........

Domain En ------------------------------------------------------ N.a.I2 ...HRDQATR KA........ ...IARARKT KVL.CVPCHK AIHGGPLPEQ N.a.I1 ...HAGFSRH MA........ ...AARQRKR MVL.CSRCHN DVHAGQPTDR L.l.I1 ...GKEKWEM AM........ ...IAKQRKT LVV.CFHCHR HVIHKHK... B.t.I2 ...GKSDWEK KM........ ...IARRRKT LAV.CSKCHA KIDPDRRIRL OYPI1 ...RKSVMNK ST........ ...KVLCIDC HRNITDQQMH DIRLNNKNKR D.h.I1 ...GERAWER VM........ ...IERRRKT LVV.CPDCYQ QIHT...... D.h.I2 ...GSHPWER VM........ ...LKMRRKT LIV.CNECHR AIHSVDSE.. Sr.me.I2 .......... .......... .......... .......... .......... E.c.I4 .......... .......... .......... .......... .......... S.f.I1 .......... .......... .......... .......... .......... C.sp.I1 .......... .......... .KDVYDNLQA LHRHCHDVKT ATDNSYNQPK G.v.I1 .......... .......... .RNISSNKQL LHRHCHHQKT AAERIQQLQS T.sp.I1 .......... .......... .DNSIKNKQL LHRHCHDTKT ALDNKTYPKL N.sp.I4 .......... .......... .KDSYDNLQL LHGHCHDAKT AEDKCAVTVP B.a.I1 .......... .......... .KDEYDNLEL LHCSCHKQHH ALLEWYGNGK B.c.I1 .......... .......... ..SNLNLKLV HLPCLY.... .......... E.c.I5 .......... .......... SNCLSNLIML HPM.CHTLVH AKGIHVVKPA A.v.I1 .......... .......... GDELDNLVLL HPN.CHRQLH SAAPALSIEK B.t.I1 LLHDSCRRKV IQTNKM.... .......... .......... .......... B.me.I2 LVHVPCIK.. .......... .......... .......... .......... A.v.I3 .......... .......... .......... .......... .......... B.f.I1 .......... .......... .......... .......... .......... B.f.I2 .......... .......... .......... .......... .......... Ma.sp.I1 .......... .......... .......... .......... .......... R.m.I1 .......... .......... SDALGNRVLL HPNCHVQVHH HGRTVVKPVL Tr.e.I8 .......... .......... .......... .......... .......... P.p.I2 .......... .......... .......... .......... .......... M.a.I1-1 .......... .......... .......... .......... .......... M.a.I1-2 .......... .......... .......... .......... .......... M.a.I1-3 .......... .......... .......... .......... .......... M.m.I1-1 .......... .......... .......... .......... .......... M.m.I1-2 .......... .......... .......... .......... .......... X.f.I1 .......... .......... SNQSGNLVMV HLN.CHYQIH NLGLDVVKPA R.r.I1 .......... .......... .......... .......... .......... P.p.I1 .......... .......... .......... .......... .......... Sr.me.I3 .......... .......... .......... .......... .......... S.p.I1 .......... .......... .......... .......... .......... S.ag.I1 .......... .......... .......... .......... .......... A.v.I2 .......... .......... .......... .......... .......... A.v.I4 .......... .......... .......... .......... .......... D.h.I3 .......... .......... .......... .......... .......... N.e.I1 .......... .......... .......... .......... .......... N.e.I2 .......... .......... .......... .......... .......... G.s.I1 .......... .......... .......... .......... .......... O.i.I1 .......... .......... .......... .......... .......... P.p.I3 .......... .......... .......... .......... .......... B.h.I1 .......... .......... .......... .......... .......... B.t.I3 .......... .......... .......... .......... .......... A.g.I1 .......... .......... .......... .......... .......... S.ma.I2 .......... .......... .......... .......... .......... M.sp.I1 .......... .......... .......... .......... .......... C.a.I1 .......... .......... .......... .......... .......... P.a.I1 .......... .......... .......... .......... .......... P.a.I2 .......... .......... .......... .......... .......... S.t.I1 .......... .......... .......... .......... .......... B.me.I1 HCHHKTPYHL TKDDSYGNLM ILHKSVHLLI HLRDLEKIQV LLNSLKLNEK C.d.I1 EVHHIKPLSL GGNDNYKNLV IVTKETHKLI HATKRETIVH YLPLVLKKER B.a.I2 HCHHKRLWSE TKDDSYKNLT IIKPSVHRLI HATKIETINQ LLNELKFNEE En.fm.I1 HCHHIVPTGA GGNDDYKNLI LVKEAVHRLI HAKTEETIQK YIALLKLNKV E.f.I3 HCHHKVPVSN GGSDEYANLI LVSKAVHILI HASSEPTIEK YLKSLNLDNK E.f.I4 HCHHYLPKSL GGDDKFDNLR IIHKDIHLLI HTTNKMIIDH YVNELKLLPE E.f.I1 ECHHINPYHL SKDDSYKNLV IISREIHRLI HATSEETILK LLRLLKLNHY E.f.I2 HCHHKKLWSE SKDDSYKNLI LLSKEMHKLV HCTDEVKIRE YIYWNKLSDS N.p.I1 NHDNWKKNNL VAIHMHCHQY IHSGTAQAEN IQEPDVAKAT RPVLKERCGR Th.e.I1 QVHSRDGQHS RSLLKEGL.. .......... .......... .......... Tr.e.I2 KI........ .......... .......... .......... .......... Tr.e.I3 .......... .......... .......... .......... .......... Tr.e.I4 RSEKGNSTSK NKELLHRHCH DTKTALERET SQSED..... .......... Tr.e.I5 .......... .......... .......... .......... .......... Tr.e.I6 GNSQDLPECY LWVNDMLTLK QGCTLELGPL TEEPDEAKVS CPVLKTSRVG Tr.e.I7 .......... .......... .......... .......... .......... Tr.e.I9 RSEGGDNTTK NKQLLHRHCH DTKTA..... .......... .......... Sr.me.I1 .......... .......... .......... .......... .......... B.j.I1 .......... .......... .......... .......... .......... R.e.I1 .......... .......... .......... .......... .......... E.c.I1 .......... .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 .......... .......... .......... .......... .......... P.l.I2 .......... .......... .......... .......... .......... M.a.I5-1 .......... .......... .......... .......... .......... M.a.I5-2 .......... .......... .......... .......... .......... M.a.I5-3 .......... .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 .......... .......... .......... .......... .......... P.l.I1 .......... .......... .......... .......... .......... Sr.me.I4 .......... .......... .......... .......... .......... S.ma.I1 .......... .......... .......... .......... .......... N.sp.I1 .......... .......... .......... .......... .......... N.sp.I2 .......... .......... .......... .......... .......... N.sp.I3 .......... .......... .......... .......... .......... Ma.sp.I2 .......... .......... .......... .......... .......... S.ag.I2 .......... .......... .......... .......... ..........

Domain En ------------------------------------------------------ N.a.I2 RT........ .......... .......... .......... .......... N.a.I1 QRRTARSRGE PNALKGARSV RRGA...... .......... .......... L.l.I1 .......... .......... .......... .......... .......... B.t.I2 N......... .......... .......... .......... .......... OYPI1 KKRINS.... .......... .......... .......... .......... D.h.I1 .......... .......... .......... .......... .......... D.h.I2 .......... .......... .......... .......... .......... Sr.me.I2 .......... .......... .......... .......... .......... E.c.I4 .......... .......... .......... .......... .......... S.f.I1 .......... .......... .......... .......... .......... C.sp.I1 SDTEINVMW. .......... .......... .......... .......... G.v.I1 QSRITEAERL QLQAKRQALL EDYQPYKSKK RLTDAEWMQQ WH........ T.sp.I1 QDLPDEYLWV NDMLILKQGC TYVKGRSGEE PDEVKVSR.. .......... N.sp.I4 ELDEDYLNLN PF........ .......... .......... .......... B.a.I1 QLPKVQAYLK SQKIPINSKK AVRTMLNTFT FKKFKY.... .......... B.c.I1 .......... .......... .......... .......... .......... E.c.I5 HESGLRKA.. .......... .......... .......... .......... A.v.I1 GLTKA..... .......... .......... .......... .......... B.t.I1 .......... .......... .......... .......... .......... B.me.I2 .......... .......... .......... .......... .......... A.v.I3 .......... .......... .......... .......... .......... B.f.I1 .......... .......... .......... .......... .......... B.f.I2 .......... .......... .......... .......... .......... Ma.sp.I1 .......... .......... .......... .......... .......... R.m.I1 EMSSIL.... .......... .......... .......... .......... Tr.e.I8 .......... .......... .......... .......... .......... P.p.I2 .......... .......... .......... .......... .......... M.a.I1-1 .......... .......... .......... .......... .......... M.a.I1-2 .......... .......... .......... .......... .......... M.a.I1-3 .......... .......... .......... .......... .......... M.m.I1-1 .......... .......... .......... .......... .......... M.m.I1-2 .......... .......... .......... .......... .......... X.f.I1 PAMGL..... .......... .......... .......... .......... R.r.I1 .......... .......... .......... .......... .......... P.p.I1 .......... .......... .......... .......... .......... Sr.me.I3 .......... .......... .......... .......... .......... S.p.I1 .......... .......... .......... .......... .......... S.ag.I1 .......... .......... .......... .......... .......... A.v.I2 .......... .......... .......... .......... .......... A.v.I4 .......... .......... .......... .......... .......... D.h.I3 .......... .......... .......... .......... .......... N.e.I1 .......... .......... .......... .......... .......... N.e.I2 .......... .......... .......... .......... .......... G.s.I1 .......... .......... .......... .......... .......... O.i.I1 .......... .......... .......... .......... .......... P.p.I3 .......... .......... .......... .......... .......... B.h.I1 .......... .......... .......... .......... .......... B.t.I3 .......... .......... .......... .......... .......... A.g.I1 .......... .......... .......... .......... .......... S.ma.I2 .......... .......... .......... .......... .......... M.sp.I1 .......... .......... .......... .......... .......... C.a.I1 .......... .......... .......... .......... .......... P.a.I1 .......... .......... .......... .......... .......... P.a.I2 .......... .......... .......... .......... .......... S.t.I1 .......... .......... .......... .......... .......... B.me.I1 .......... .......... .......... .......... .......... C.d.I1 SLEKLNKLRA LAGNSEIEMN Y......... .......... .......... B.a.I2 QLGKLNKLRK LVKNEEICI. .......... .......... .......... En.fm.I1 QLIRLNKYRV LAGNQELNLI .......... .......... .......... E.f.I3 QIEKLNKLRS MAEMPPIIL. .......... .......... .......... E.f.I4 QIAKINLYRK MCNLQNIQ.. .......... .......... .......... E.f.I1 QIRKLNTYRK KAANFPISIK MN........ .......... .......... E.f.I2 QVNKVNKLRK LVNKTIILPL CEQMPKYEQL TLF....... .......... N.p.I1 .......... .......... .......... .......... .......... Th.e.I1 .......... .......... .......... .......... .......... Tr.e.I2 .......... .......... .......... .......... .......... Tr.e.I3 .......... .......... .......... .......... .......... Tr.e.I4 .......... .......... .......... .......... .......... Tr.e.I5 .......... .......... .......... .......... .......... Tr.e.I6 .......... .......... .......... .......... .......... Tr.e.I7 .......... .......... .......... .......... .......... Tr.e.I9 .......... .......... .......... .......... .......... Sr.me.I1 .......... .......... .......... .......... .......... B.j.I1 .......... .......... .......... .......... .......... R.e.I1 .......... .......... .......... .......... .......... E.c.I1 .......... .......... .......... .......... .......... E.c.I3 .......... .......... .......... .......... .......... E.c.I2 .......... .......... .......... .......... .......... P.l.I2 .......... .......... .......... .......... .......... M.a.I5-1 .......... .......... .......... .......... .......... M.a.I5-2 .......... .......... .......... .......... .......... M.a.I5-3 .......... .......... .......... .......... .......... UMB .......... .......... .......... .......... .......... A.v.I5 .......... .......... .......... .......... .......... B.j.I2 .......... .......... .......... .......... .......... P.l.I1 .......... .......... .......... .......... .......... Sr.me.I4 .......... .......... .......... .......... .......... S.ma.I1 .......... .......... .......... .......... .......... N.sp.I1 .......... .......... .......... .......... .......... N.sp.I2 .......... .......... .......... .......... .......... N.sp.I3 .......... .......... .......... .......... .......... Ma.sp.I2 .......... .......... .......... .......... .......... S.ag.I2 .......... .......... .......... .......... ..........

------------------------| N.a.I2 .......... .......... ... N.a.I1 .......... .......... ... L.l.I1 .......... .......... ... B.t.I2 .......... .......... ... OYPI1 .......... .......... ... D.h.I1 .......... .......... ... D.h.I2 .......... .......... ... Sr.me.I2 .......... .......... ... E.c.I4 .......... .......... ... S.f.I1 .......... .......... ... C.sp.I1 .......... .......... ... G.v.I1 .......... .......... ... T.sp.I1 .......... .......... ... N.sp.I4 .......... .......... ... B.a.I1 .......... .......... ... B.c.I1 .......... .......... ... E.c.I5 .......... .......... ... A.v.I1 .......... .......... ... B.t.I1 .......... .......... ... B.me.I2 .......... .......... ... A.v.I3 .......... .......... ... B.f.I1 .......... .......... ... B.f.I2 .......... .......... ... Ma.sp.I1 .......... .......... ... R.m.I1 .......... .......... ... Tr.e.I8 .......... .......... ... P.p.I2 .......... .......... ... M.a.I1-1 .......... .......... ... M.a.I1-2 .......... .......... ... M.a.I1-3 .......... .......... ... M.m.I1-1 .......... .......... ... M.m.I1-2 .......... .......... ... X.f.I1 .......... .......... ... R.r.I1 .......... .......... ... P.p.I1 .......... .......... ... Sr.me.I3 .......... .......... ... S.p.I1 .......... .......... ... S.ag.I1 .......... .......... ... A.v.I2 .......... .......... ... A.v.I4 .......... .......... ... D.h.I3 .......... .......... ... N.e.I1 .......... .......... ... N.e.I2 .......... .......... ... G.s.I1 .......... .......... ... O.i.I1 .......... .......... ... P.p.I3 .......... .......... ... B.h.I1 .......... .......... ... B.t.I3 .......... .......... ... A.g.I1 .......... .......... ... S.ma.I2 .......... .......... ... M.sp.I1 .......... .......... ... C.a.I1 .......... .......... ... P.a.I1 .......... .......... ... P.a.I2 .......... .......... ... S.t.I1 .......... .......... ... B.me.I1 .......... .......... ... C.d.I1 .......... .......... ... B.a.I2 .......... .......... ... En.fm.I1 .......... .......... ... E.f.I3 .......... .......... ... E.f.I4 .......... .......... ... E.f.I1 .......... .......... ... E.f.I2 .......... .......... ... N.p.I1 .......... .......... ... Th.e.I1 .......... .......... ... Tr.e.I2 .......... .......... ... Tr.e.I3 .......... .......... ... Tr.e.I4 .......... .......... ... Tr.e.I5 .......... .......... ... Tr.e.I6 .......... .......... ... Tr.e.I7 .......... .......... ... Tr.e.I9 .......... .......... ... Sr.me.I1 .......... .......... ... B.j.I1 .......... .......... ... R.e.I1 .......... .......... ... E.c.I1 .......... .......... ... E.c.I3 .......... .......... ... E.c.I2 .......... .......... ... P.l.I2 .......... .......... ... M.a.I5-1 .......... .......... ... M.a.I5-2 .......... .......... ... M.a.I5-3 .......... .......... ... UMB .......... .......... ... A.v.I5 .......... .......... ... B.j.I2 .......... .......... ... P.l.I1 .......... .......... ... Sr.me.I4 .......... .......... ... S.ma.I1 .......... .......... ... N.sp.I1 .......... .......... ... N.sp.I2 .......... .......... ... N.sp.I3 .......... .......... ... Ma.sp.I2 .......... .......... ... S.ag.I2 .......... .......... ...

General Information

Specific introns

Tools and Analysis

Other

Definition of domains based on a sequence alignment of bacterial intron encoded ORFs